semantic processing disturbance in patients with schizophrenia a meta-analysis of the n400 component语义加工障碍在精神分裂症患者n400的荟萃分析组件.pdfVIP
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semantic processing disturbance in patients with schizophrenia a meta-analysis of the n400 component语义加工障碍在精神分裂症患者n400的荟萃分析组件
Semantic Processing Disturbance in Patients with
Schizophrenia: A Meta-Analysis of the N400 Component
1 2 3 1
Kui Wang , Eric F. C. Cheung , Qi-yong Gong , Raymond C. K. Chan *
1 Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing,
China, 2 Castle Peak Hospital, Hong Kong Special Administrative Region, China, 3 Huaxi MR Research Centre, Department of Radiology, West China Hospital/West China
School of Medicine, Sichuan University, Chengdu, China
Abstract
Background: Theoretically semantic processing can be separated into early automatic semantic activation and late
contextualization. Semantic processing deficits have been suggested in patients with schizophrenia, however it is not clear
which stage of semantic processing is impaired. We attempted to clarify this issue by conducting a meta-analysis of the
N400 component.
Methods: Twenty-one studies met the inclusion criteria for the meta-analysis procedure. The Comprehensive Meta-Analysis
software package was used to compute pooled effect sizes and homogeneity.
Results: Studies favoring early automatic activation produced a significant effect size of 20.41 for the N400 effect. Studies
favoring late contextualization generated a significant effect size of 20.36 for the N400 effect, a significant effect size of
20.52 for N400 for congruent/related target words, and a significant effect size of 0.82 for the N400 peak latency.
Conclusion: These findings suggest the automatic spreading activation process in patients with schizophrenia is very similar
for closely related concepts and weakly or remotely related concepts, while late contextualization may be associated with
impairment
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