shiga toxin receptor gb3cercd77 tumor-association and promising therapeutic target in pancreas and colon cancer志贺毒素受体gb3cercd77 tumor-association并承诺在胰腺癌和结肠癌的治疗目标.pdfVIP

Shiga Toxin Receptor Gb3Cer/CD77: Tumor-Association and Promising Therapeutic Target in Pancreas and Colon Cancer 1 2 ¨ 1 ´ 3 ¨ 4 Ute Distler , Jamal Souady , Marcel Hulsewig , Irena Drmic-Hofman , Jorg Haier , Alexander W. 1 1 4 2 5 Friedrich , Helge Karch , Norbert Senninger , Klaus Dreisewerd , Stefan Berkenkamp , M. Alexander 6 ´2 ¨ 1 Schmidt , Jasna Peter-Katalinic , Johannes Muthing * ¨ ¨ ¨ ¨ 1 Institute of Hygiene, University of Munster, Munster, Germany, 2 Institute of Medical Physics and Biophysics, University of Munster, Munster, Germany, 3 Department of Pathology, Laboratory for Clinical and Forensic Genetics, University Hospital and Medical School Split, Split, Croatia, 4 Department of General Surgery, University Hospital ¨ ¨ ¨ ¨ Munster, Munster, Germany, 5 Sequenom GmbH, Hamburg, Germany, 6 Institute of Infectiology, University of Munster, Munster, Germany Abstract Background: Despite progress in adjuvant chemotherapy in the recent decades, pancreatic and colon cancers remain common causes of death worldwide. Bacterial toxins, which specifically bind to cell surface-exposed glycosphingolipids, are a potential novel therapy. We determined the expression of globotriaosylceramide (Gb3Cer/CD77), the Shiga toxin receptor, in human pancreatic and colon adenocarcinomas. Methodology/Principal Findings: Tissue lipid ext