原创力文档short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index短睡眠时间与降低瘦素,饥饿激素升高,身体质量指数增加.pdfVIP
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short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index短睡眠时间与降低瘦素,饥饿激素升高,身体质量指数增加
Open access, freely available online PLoS MEDICINE
Short Sleep Duration Is Associated
with Reduced Leptin, Elevated Ghrelin,
and Increased Body Mass Index
1¤ 1 2 2 1*
Shahrad Taheri , Ling Lin , Diane Austin , Terry Young , Emmanuel Mignot
1 Howard Hughes Medical Institute, Stanford University, Palo Alto, California, United States of America, 2 Department of Population Health Sciences, University of Wisconsin,
Madison, Wisconsin, United States of America
Competing Interests: The authors
have declared that no competing
interests exist. A B S T R A C T
Author Contributions: ST, TY, and
EM designed the study. ST, DA, TY, Background
and EM analyzed the data. ST, LL,
and EM performed the experi- Sleep duration may be an important regulator of body weight and metabolism. An
ments. TY enrolled patients. ST, association between short habitual sleep time and increased body mass index (BMI) has been
LL, DA, TY, and EM contributed to
writing the paper. reported in large population samples. The potential role of metabolic hormones in this
association is unknown.
Academic Editor: Philippe Froguel,
Centre National de la Recherche
Scientifique Institut de Biologie de Methods and Findings
Lille, France
Study participants were 1,024 volunteers from the Wisconsin Sleep Cohort Study, a
Citation: Taheri S, Lin L, Austin D, population-based longitudinal study of sleep disorders. Participants underwent nocturnal
Young T, Mignot E (
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