single liver lobe repopulation with wildtype hepatocytes using regional hepatic irradiation cures jaundice in gunn rats单一肝脏叶重新使用区域与野生型肝细胞肝照射治疗黄疸耿氏老鼠.pdfVIP

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single liver lobe repopulation with wildtype hepatocytes using regional hepatic irradiation cures jaundice in gunn rats单一肝脏叶重新使用区域与野生型肝细胞肝照射治疗黄疸耿氏老鼠.pdf

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single liver lobe repopulation with wildtype hepatocytes using regional hepatic irradiation cures jaundice in gunn rats单一肝脏叶重新使用区域与野生型肝细胞肝照射治疗黄疸耿氏老鼠

Single Liver Lobe Repopulation with Wildtype Hepatocytes Using Regional Hepatic Irradiation Cures Jaundice in Gunn Rats 1 1 1 2 2 2 Hongchao Zhou , Xinyuan Dong , Rafi Kabarriti , Yong Chen , Yesim Avsar , Xia Wang , 2 1 3 2 2 Jianqiang Ding , Laibin Liu , Ira J. Fox , Jayanta Roy-Chowdhury , Namita Roy-Chowdhury *, Chandan Guha1* 1 Departments of Radiation Oncology and Pathology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America, 2 Departments of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, New York, United States of America, 3 Department of Surgery, University of Pittsburgh School of Medicine, Children’s Hospital of Pittsburgh of UPMC and McGowan Institute of Regenerative Medicine, Pittsburgh, Pennsylvania, United States of America Abstract Background and Aims: Preparative hepatic irradiation (HIR), together with mitotic stimulation of hepatocytes, permits extensive hepatic repopulation by transplanted hepatocytes in rats and mice. However, whole liver HIR is associated with radiation-induced liver disease (RILD), which limits its potential therapeutic application. In clinical experience, restricting HIR to a fraction of the liver reduces the susceptibility to RILD. Here we test the hypothesis that repopulation of selected liver lobes by regional HIR should be sufficient to correct some inherited metabolic disorders. 7 Methods: Hepatocytes (10 ) isolated from wildtype F344 rats or Wistar-RHA rats were engrafted into the livers of congeneic dipeptidylpeptidase IV deficien