原创力文档six-year follow-up of impact of co-proxamol withdrawal in england and wales on prescribing and deaths time-series study六年的后续影响co-proxamol撤军在英格兰和威尔士的处方和死亡时间序列研究.pdfVIP
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six-year follow-up of impact of co-proxamol withdrawal in england and wales on prescribing and deaths time-series study六年的后续影响co-proxamol撤军在英格兰和威尔士的处方和死亡时间序列研究
Six-Year Follow-Up of Impact of Co-proxamol Withdrawal
in England and Wales on Prescribing and Deaths: Time-
Series Study
1 1 1 2 3 4
Keith Hawton *, Helen Bergen , Sue Simkin , Claudia Wells , Navneet Kapur , David Gunnell
1 Centre for Suicide Research, University of Oxford Department of Psychiatry, Warneford Hospital, Headington, Oxford, United Kingdom, 2 Office for National Statistics,
Government Buildings, Newport, United Kingdom, 3 Centre for Suicide Prevention, University of Manchester, Manchester, United Kingdom, 4 School of Social and
Community Medicine, University of Bristol, Bristol, United Kingdom
Abstract
Background: The analgesic co-proxamol (paracetamol/dextropropoxyphene combination) has been widely involved in fatal
poisoning. Concerns about its safety/effectiveness profile and widespread use for suicidal poisoning prompted its
withdrawal in the UK in 2005, with partial withdrawal between 2005 and 2007, and full withdrawal in 2008. Our objective in
this study was to assess the association between co-proxamol withdrawal and prescribing and deaths in England and Wales
in 2005–2010 compared with 1998–2004, including estimation of possible substitution effects by other analgesics.
Methods and Findings: We obtained prescribing data from the NHS Health and Social Care Information Centre (England)
and Prescribing Services Partneriaeth Cydwasanaethau GIG Cymru (Wales), and mortality data from the Office for National
Statistics. We carried out an interrupted time-series analysis of prescribing and deaths (suicide, open verdicts, accidental
poisonings) involving single analgesics. The reduction in prescribing of co-proxamol following its withdrawal in 2005 was
accompanied by increase
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