spatial predictions of rhodesian human african trypanosomiasis (sleeping sickness) prevalence in kaberamaido and dokolo, two newly affected districts of uganda空间预测的罗德西亚非洲人类锥虫病(昏睡病)流行kaberamaido dokolo,乌干达的两个新疫区.pdfVIP

Spatial Predictions of Rhodesian Human African Trypanosomiasis (Sleeping Sickness) Prevalence in Kaberamaido and Dokolo, Two Newly Affected Districts of Uganda 1,2 2 3 1 ` 4 Nicola A. Batchelor , Peter M. Atkinson , Peter W. Gething , Kim Picozzi , Eric M. Fevre , Abbas S. L. 5 1 Kakembo , Susan C. Welburn * 1 Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom, 2 School of Geography, Highfield Campus, University of Southampton, Southampton, United Kingdom, 3 Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, United Kingdom, 4 Centre for Infectious Diseases, College of Science and Engineering, University of Edinburgh, Edinburgh, United Kingdom, 5 Ministry of Health, Department of National Disease Control, Ministry of Health, Nakasero, Kampala, Uganda Abstract The continued northwards spread of Rhodesian sleeping sickness or Human African Trypanosomiasis (HAT) within Uganda is raising concerns of overlap with the Gambian form of the disease. Disease convergence would result in compromised diagnosis and treatment for HAT. Spatial determinants for HAT are poorly understood across small areas. This study examines the relationships between Rhodesian HAT and several environmental, climatic and social factors in two newly affected districts, Kaberamaido and Dokolo. A one-step logistic regression analysis of HAT prevalence and a two-step logistic regression method permitted separate analysis of both HAT occurrence and HAT prevalence. Both the occurrence and prevalence of HAT were negatively correlated with distance to the closest livestock market in al