原创力文档single dermavir immunization dose-dependent expansion of precursormemory t cells against all hiv antigens in hiv-1 infected individuals单一dermavir precursormemory t细胞的免疫剂量依赖性扩张对所有艾滋病毒抗原在hiv - 1感染者.pdfVIP
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single dermavir immunization dose-dependent expansion of precursormemory t cells against all hiv antigens in hiv-1 infected individuals单一dermavir precursormemory t细胞的免疫剂量依赖性扩张对所有艾滋病毒抗原在hiv - 1感染者
Single DermaVir Immunization: Dose-Dependent
Expansion of Precursor/Memory T Cells against All HIV
Antigens in HIV-1 Infected Individuals
1 2 2 ´ ´ 3 ´ ´ 3
Julianna Lisziewicz *, Nyasha Bakare , Sandra A. Calarota , Denes Banhegyi , Janos Szlavik ,
´ 3 1 ´ 1 1 4 2
Eszter Ujhelyi , Eniko˝ R. To˝ ke , Levente Molnar , Zsolt Lisziewicz , Brigitte Autran , Franco Lori
1 Genetic Immunity, Budapest, Hungary and Genetic Immunity Inc, Mclean, Virginia, United States of America, 2 The Research Institute for Genetic and Human Therapy,
´ ´
Cambridge, Massachusetts, United States of America, 3 Szent Laszlo Hospital, Budapest, Hungary, 4 Laboratoire d’ Immunologie Cellulaire, Centre Hospitalier Universitaire
´ ´ `
Pitie-Salpetriere, Paris, France
Abstract
Background: The GIHU004 study was designed to evaluate the safety and immunogenicity of three doses of DermaVir
immunization in HIV-infected subjects on fully suppressive combination antiretroviral therapy (cART).
Methodology/Principal Findings: This first-in-human dose escalation study was conducted with three topical DermaVir
doses targeted to epidermal Langerhans cells to express fifteen HIV antigens in draining lymph nodes: 0.1 mg DNA targeted
to two, 0.4 mg and 0.8 mg DNA targeted to four lymph nodes. Particularly, in the medium dose cohort 0.1 mg DNA was
targeted per draining lymph node via ,8 million Langerhans cells located in 80 cm
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