stat3 activates the receptor tyrosine kinase like orphan receptor-1 gene in chronic lymphocytic leukemia cells像孤儿receptor-1 stat3激活受体酪氨酸激酶基因在慢性淋巴细胞白血病细胞.pdfVIP

Stat3 Activates the Receptor Tyrosine Kinase Like Orphan Receptor-1 Gene in Chronic Lymphocytic Leukemia Cells Ping Li, David Harris, Zhiming Liu, Jie Liu, Michael Keating, Zeev Estrov* Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America Abstract Background: The receptor tyrosine kinase like orphan receptor (ROR)-1 gene is overexpressed in chronic lymphocytic leukemia (CLL). Because Stat3 is constitutively activated in CLL and sequence analysis revealed that the ROR1 promoter