影响自体活性物质的的药物.pptVIP

第 33 章 影响自体活性物质的药物 Chapter33 Drugs Affecting Autacoids; Autacoids have been described as local hormones. They are grouped together in large part because they participate, at least in some settings, in physiological or pathophysiological response to injury. Although these substances function in humoral regulation, they cannot be classed convieniently with other members of this broad group, because these substances usually have a brief lifetime and act near their sites of synthesis. Autacoids includs prostaglandins, histamin, 5-hydroxytryptamine, leukotrienes and vessel intestinal peptides vessel intestinal peptides etc. They have diverse physiological and pharmacological activities. Drugs elaborated in this chapter include natural and synthetic autacoids and inhibitors that inhibit or interfere the actions between autacoids and their receptors. ; 什么是自体活性物质？;第一节 组胺;第二节 抗组胺药;;第三节 膜??脂代谢产物类药物及阻断药;;;;;;;;;二、血管紧张素 三、利尿钠肽 四、P物质 P物质（substance P，SP）是一种由11个氨 基酸组成的多肽，作用广泛。 第一，SP具有强大的血管舒张作用，特别是对小动脉，从而产生显著的降压作用。与其他血管舒张药不同，SP 可收缩静脉血管。 第二，具有强烈的内脏平滑肌兴奋作用，引起支气管平滑肌强烈收缩和胃肠道及子宫平滑肌的节律性收缩。 第三，可刺激唾液分泌和排钠利尿。 第四，可刺激肥大细胞脱颗粒以及巨噬细胞合成、释放溶酶、LTC4、PGD2、TXB等花生四烯酸代谢物。 五、内皮素 六、其他;;第 33 章学习结束