LARS人工韧带重建前交叉韧带生物相容性及与骨组织的愈合.docVIP

LARS人工韧带重建前交叉韧带：生物相容性及与骨组织的愈合 翟昕元1，林小风2 (1三峡大学体育学院，湖北省宜昌市 443002；2长江大学医学院，湖北省荆州市 434023) 引用本文：翟昕元，林小风. LARS人工韧带重建前交叉韧带：生物相容性及与骨组织的愈合[J].中国组织工程研究，2017，21(): 2565-2569. DOI:10.3969/j.issn.2095-4344.2017.16.018 ORCID: 0000-0001-8999-4141(翟昕元) 文章快速阅读： 文题释义： LARS人工带：重建前交叉韧带损伤的移植物：Reconstruction of the anterior cruciate ligament using Ligament Advanced Reinforcement System: its biocompatibility and bone healing Zhai Xin-yuan1, Lin Xiao-feng2 (1Institute of Physical Education of China Three Gorges University, Yichang 443002, Hubei Province, China; 2Medical School of Yangtze University, Jingzhou 434023, Hubei Province, China) Abstract BACKGROUND: Ligament Advanced Reinforcement Sytstm (LARS) artificial ligament can avoid the interfibrillar friction compared wiht traditional ligaments, which is conductive for autogenous tissue growth. OBJECTIVE: To investigate the biocompatibility of LARS artificial ligament used for cruciate ligament reconstruction and bone healing. METHODS: Twenty goats were randomly divided into two groups: the anterior cruciate ligament insertion at the femur was cut as stump group; the anterior cruciate ligament insertions at the femur and tibia, and all the ligaments and synovial tissues between them were cut as stump resection group. LARS artificial ligament was then implanted into both two groups. At 20 months after implantation, the ligament healing was observed using CT and MRI examinations, the fibrous tissues were observed under scanning electron microscope, and the growth of newborn ligaments was observed by histological staining. RESULTS AND CONCLUSION: CT findings showed that in the stump group, the number of femoral tunnel enlargement was significantly more than that in the stump resection group (P 0.05), while the number of tibial tunnel enlargement in the stump group was significantly less than that in the stump resection group (P 0.05). LARS artificial ligament in the femoral and tibial tunnel and free part of the joint pre