单核因子与血清阴性脊柱关节病（Single nucleotide factor and seronegative spinal arthropathy）.docVIP

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单核因子与血清阴性脊柱关节病（Single nucleotide factor and seronegative spinal arthropathy）.doc

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单核因子与血清阴性脊柱关节病（Single nucleotide factor and seronegative spinal arthropathy）

单核因子与血清阴性脊柱关节病（Single nucleotide factor and seronegative spinal arthropathy） Single nucleotide factor and seronegative spinal arthropathy 2011-09-13 Zhao Wei Huang Feng MKs (monokines) is a small polypeptide secreted by activated monocytes / macrophages that mediates and modulates immune and inflammatory responses. In recent years, the relationship between the biological effects of these peptides and rheumatic diseases has aroused widespread concern in the field of rheumatology. A number of studies have shown that MKs is involved in the pathogenesis of seronegative SpA, and summarizes the progress in the biological activity of MKs and its role in the pathogenesis of SpA. 1 biological effects of single nucleotide factor Such as IL-1, IL-6, IL-8, IL-12, IL-18, tumor necrosis factor alpha in many immune cells were stimulated (TNF- alpha), granulocyte monocyte colony stimulating factor (GM-CSF) and other proinflammatory factors, due mainly from the mononuclear cells and the cytokines (cytokines, CKs) due to the single nuclear factor. Monocytes are involved in immune and inflammatory reactions mainly through antigen presentation, processing and secretion of MKs. These small molecules are not only synergistic, but also interact with other CK, which interact in a dose - or time-dependent manner. Various MKs have their unique biological characteristics. TNF- alpha: TNF- alpha is the most extensively studied and thoroughly studied CK, GM-CSF, IL-1, CK and some biological factors can stimulate its secretion [1], while IL-6, prostaglandin E2 can down regulate the level of TNF- alpha. In vivo effects of TNF- alpha in a dose-dependent manner: low concentration (10 - 9 mol/L) mainly stimulating local inflammation, mononuclear cells and other cells to produce IL-1, GM-CSF and other proinflammatory factors to its amplification effect; promote IL-1, IL-6 and acute phase response of egg Bai Shengcheng medium concentration, has a protective effect; TNF- alpha extreme can lead to a sig