肠易激综合症（Irritable bowel syndrome）.docVIP

肠易激综合症（Irritable bowel syndrome） Irritable bowel syndrome (IBS) Overview of important points Definition As early as 1993, there is a more authoritative definition: IBS is a non organic functional gastrointestinal disorders, due to genetic and psychological factors that lead to susceptibility to gastrointestinal function, gastrointestinal motility, abnormal changes of visceral sensitivity and mucosal immunity, the patient is associated with changes abdominal pain and defecation or defecation habits or discomfort, and defecation disorders. Incidence Chinese and foreign scholars have statistics that the IBS and 10%-20% of adults and adolescents in the global population are more common than men. Symptoms often occur again and again. About 2/3 of patients often overlap with other FGID. IBS can seriously affect the quality of life of patients and lead to a large number of medical expenses. It is the most typical psychosomatic disease in FGID. Etiology and mechanism The general cause is the interaction of stress response and psychological factors, different individuals may involve genetic, environmental and psychological, social and other factors lead to gastrointestinal infection, gastrointestinal motility, visceral hypersensitivity, brain gut axis interaction disorders, autonomic and hormonal changes, associated with mental disorders (such as panic, anxiety and post-traumatic stress disorder), sleep disorders and psychological disorder, stressful life events can often lead to a worsening of symptoms, but the exact relationship between psychological factors and IBS ten is not clear. In recent years, the study found that 1/3 IBS patients with gastrointestinal infection, both at home and abroad have emphasized the influence of psychological factors on the pathogenesis of IBS, and pay more attention to the neuropeptide receptor function in the pathogenesis of IBS; in recent years it has strengthened IBS and inflammatory bowel disease (IBD) relationship between studies, few s