不同给药速度经兔肝动脉灌注5-氟脲嘧啶之药代动力学变化分析研究.pdfVIP

A 0／I Pharmacokinetic5-Fluoroubacilwhenitwas Study infused Rabbit’S through HepaticArtery Different By Velocity Su PostgradateYuanHong TutorProfLiu Feilong of iMedical Department Tongji Hospital，TonN University Abstract observe of5． Purpose：to pharmacokinetic change concentrationswhen Fluoroubacil(5-Fu)by measuringdrug’S itwas infused rabbit’S different through hepaticartery by doseof in velocity．Methods：Same 5-Fu(20mg／kg weight 20ml 0．9％sodium chloride、was rabbit’S given through artery of hepatic bywaysrapidinfusion(RI group，4ml／min) andslow infusion(SI 5、30、60、90and group，0．5ml／min)5、1 120minutes tissues later，liverand blood were peripheral collected．The concentrations