新辅助化疗联合保乳术治疗早期乳腺癌19例临床研究.docVIP

新辅助化疗联合保乳术治疗早期乳腺癌19例临床研究[摘要] 目的:总结新辅助化疗联合保乳术治疗早期乳腺癌的方法及注意事项。方法:对2005年2月～2008年3月在本院行新辅助化疗联合保乳术治疗的19例早期乳腺癌患者的临床资料进行回顾性分析。结果:19例患者均顺利完成2～3个周期的化疗,化疗结束1周后,成功实施保乳手术,术后行综合治疗,随访1～3年,全部无瘤生存,术后1年89.47%的患者对自身乳房外形满意。结论:新辅助化疗联合保乳术疗效肯定,副反应轻,并发症发生率低,对符合条件的早期乳腺癌患者可灵活选用此治疗方法。 [关键词] 新辅助化疗;保乳术;早期乳腺癌;回顾性分析 [中图分类号] R737.9 [文献标识码]A [文章编号]1674-4721(2010)03(b)-033-02 The neoadjuvant chemotherapy combined with breast-conserving treatment of early breast cancer clinical analysis of nineteen cases ZHANG Ronggui (Cancer Center,Traditional Chinese Hospital of Liuan City of Anhui University of Traditional Chinese Medicine,Liuan237000, China) [Abstract] Objective: Summary of neoadjuvant chemotherapy combined with breast-conserving treatment of early breast cancer,methods and precautions. Methods: Nineteen patients with early breast cancer were treated from February 2005 to March 2008. Results: Nineteen patients were successfully completed two to three cycles of chemotherapy, one week after the end of chemotherapy,the successful implementation of breast-conserving surgery, after a holistic treatment, follow-up one to three years, all tumor-free survival after one year 89.47% patients were satisfied with their breast appearance. Conclusion: Neoadjuvant chemotherapy combined with breast-conserving surgery positive effects, side effects of light, the low rate of complications, for eligible patients with early breast cancer can be flexibly chosen for this treatment. [Key words] Neo-adjuvant chemotherapy; Breast-conserving surgery; Early stage breast cancer; Retrospective analysis 乳腺癌是指发生在乳腺导管上皮的恶性肿瘤。新辅助化疗亦称术前化疗、首次化疗,是指在局部治疗前进行的化学药物治疗。保留乳房治疗(breast-conserving therapy,BCT)是指保留乳腺的手术,其中包括局部肿块切除、腺段切除和象限切除,加上腋窝淋巴结清扫;术后辅以放疗、化疗及内分泌治疗等综合治疗[1]。2005年2月～2008年3月,笔者所在医院肿瘤防治中心对收治的19例早期乳腺癌患者采用新辅助化疗联合保乳术治疗,取得了较好效果,现报道如下: 1 资料与方法 1.1 一般资料 本组患者共19例,年龄37～56岁,平均42.7岁。全部患者术前均经过X线钼靶摄片和(或)CT扫描、乳腺彩超、血清癌标志物检测及病理检查确诊。肿瘤均为单发,其中发生左乳者11例,右乳者7例,双侧同时发生者1例;肿块位于外上象限12例,内上象限7例。肿块直径为1.0～3.8 cm,其中肿块直径1.0～