1H-MRS在高级别脑胶质瘤及脑转移瘤鉴别诊断中应用.docVIP

1H-MRS在高级别脑胶质瘤及脑转移瘤鉴别诊断中应用 　 作者:王雁冰 徐锐 张通 　　【摘要】 目的 探讨T 1H-MRS在高级别脑胶质瘤与脑转移瘤中诊断及鉴别诊断的价值。方法 选取经手术病理或临床确诊的30例高级别脑胶质瘤与脑转移瘤患者。采用美国GE公司Signa EXCITE HD 3.0T 超导型MR扫描仪对所有患者行颅脑常规MRl扫描和二维多体素144 ms序列扫描。采用Functool软件包后处理,分别测定瘤体区、瘤周区及健侧相应区域的胆碱/肌酸(Cho/Cr)、胆碱/氮-乙酞天门冬氨酸(Cho/NAA)、氮-乙酞天门冬氨酸/肌酸(NAA/Cr)比值的变化,并对结果利用SPSS13.0软件包进行统计学分析。结果 高级别胶质瘤和转移瘤瘤体区Cho/NAA值比较差异有统计学意义(Plt;0.05),而Cho/Cr、NAA/Cr值分别比较差异无统计学意义(Pgt;0.05);瘤周区Cho/Cr、Cho/NAA值比较差异有统计学意义(Plt;0.05),NAA/Cr值比较差异无统计学意义(Pgt;0.05)。结论 1H-MRS在鉴别诊断高级别胶质瘤和转移瘤中有重要价值,对瘤周区的Cho/Cr、Cho/NAA值的检查是鉴别胶质瘤和转移瘤的重要手段,特别对于单发脑转移瘤更具鉴别意义。 　　【关键词】质子磁共振波谱;颅内肿瘤;多体素;鉴别诊断 　　【Abstract】 Objective To investigate the value in MR spectrum in differentialdiagnosis between high grade gliomas and metastases.Methods 30 cases of patients who confirmed by histopathologic findings or clinical follow-up were collected.Using a GE Signa EXCITE HD 3.0T super conduct MR unit,all the cases of patients were performed conventional MR scan and mutlti-voxel with 2-D mutlti-voxel PRESS 144 ms.Functool software was used for post-processing of spectrum.The ratios of NAA/Cr,NAA/Cho,Cho/Cr were measured in the solid part of masses,circum of tumors and contralateral parenchyma respectively.The result was used as the statistical method by SPSS13.0 software.Results In the solid part of masses,there were significant differences between high grade gliomas and metastases in the ratios of Cho/NAA(Plt;0.05),but no differences in the ratios of Cho/Cr,NAA/Cr;In peritumoral edema,there were significant differences in the ratios of Cho/Cr,Cho/NAA(Plt;0.05),but no significant differences in the ratios of NAA/Cr(Plt;0.05).Conclusion 1H-MRS is very important and useful in the evaluation of differentialdiagnosis between high grade gliomas and metastases.The inspections of the ratios of Cho/Cr,Cho/NAA of gliomas and metastases peritumoral edema are important methods,especially for solitary metastases. 　　【Key words】 　　1H-magnetic resonance spectroscopy; Gliomas; Multivoxel; Differential diagno