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Burkitt’s Lymphoma- Clinicopathologic Features and Differen
Burkitt’s Lymphoma: Clinicopathologic Features and Differen
【关键词】 Burkitts,lymphoma,amp;#8226;,Immunophenotype,amp;#8226;,c-myc,amp;#8226;,Outcome,amp;#8226;,Differential,diagnosis
LEARNING OBJECTIVES
After completing this course, the reader will be able to:
Describe the events leading to the initial identification and description of Burkitt’s lymphoma and the discovery of its association with the Epstein-Barr virus.
Outline the WHO Classification of Burkitts lymphoma, including the clinical and pathological variants of this lymphoma.
Discuss the treatment strategies used for treating Burkitts lymphoma.
List the criteria for establishing a diagnosis of Burkitts lymphoma and discuss the entities that may enter its differential diagnosis.
ABSTRACT
Burkitts lymphoma is a highly aggressive lymphoma identified and described in the last century by Denis Burkitt in Africa, in areas endemic for malaria. Since its description in African children, it has been recognized outside areas with endemic malaria, frequently also in children as well as among individuals with an underlying immunodeficiency. Since its initial designation as Burkitt?s lymphoma, this type of lymphoma and lymphomas closely resembling it have received a variety of names in different classifications of lymphomas and leukemias: undifferentiated lymphoma, Burkitt?s and non-Burkitt?s type in the modified Rappaport Classification, malignant lymphoma, small non-cleaved cell, Burkitt?s type in the Working Formulation, Burkitt?s lymphoma and high-grade B-cell lymphoma, Burkitt-like in the REAL Classification, and acute lymphoblastic leukemia, L3 type in the FAB Classification. With the publication of the WHO Classification of Haematopoietic and Lymphoid Tumors, the nomenclature of this lymphoma has come full circle, and it is once again known simply as Burkitt?s lymphoma. In recent years, efforts have focused on improving therapy for this rapidly proliferating neoplasm while minimizing,
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