Gelsolin蛋白及非小细胞肺癌转移关系.docVIP

Gelsolin蛋白及非小细胞肺癌转移关系 　 作者：竺王玉，周吉航，黄燕燕，刘晓光，张永奎 【摘要】 目的 ： 探讨凝溶胶蛋白(Gelsolin)在预测非小细胞肺癌(non-small cell lung cancer，NSCLC)临床病理特征、癌细胞转移和患者预后中的价值。方法：采用SP免疫组化法检测63例有完整资料的NSCLC患者癌组织标本及63例癌旁组织标本Gelsolin蛋白表达，分析Gelsolin与NSCLC患者临床病理特征和转移、预后的关系。结果：Gelsolin蛋白在63例癌旁组织中均为弱阳性表达，在肺癌细胞中的阳性表达率为31.7%(20/63);Gelsolin蛋白阳性表达与NSCLC组织学类型、肿瘤分化程度、肿瘤大小、临床分期及淋巴结转移有关(Plt;0.05);Kaplan-Meier生存分析显示Gelsolin蛋白阳性患者生存率较Gelsolin蛋白弱阳性或阴　　性患者为低(Plt;0.05);Cox风险比例模型显示淋巴结转移及Gelsolin蛋白阳性可显著增加NSCLC患者的死亡风险(Plt;0.05)。结论：Gelsolin基因在NSCLC发生发展中起重要作用，与NSCLC转移及低生存率有关，可作为临床早期发现NSCLC转移及预测预后的指标。 【关键词】 癌，非小细胞肺;凝溶胶蛋白;转移;预后 　Abstract: Objective: To probe the value of Gelsolin in the prediction of theclinicopatho-logical features，metastasis of cancerous cell and prognosis of patients withnon-small cell lung cancer (NSCLC). Methods: SP immunohistochemical was used to detect theexpression of Gelsolin protein in 63 lung carcinoma and 20 paracancerous tissue.Results: Thepositive rate of Gelsolin protein in lung carcinoma was 31.7%(20/63)while the exprssion of lungparacacerous tissues was all weakly positive.In the carcinoma tissues，the positive expressionof Gelsolin protein in NSCLC was signifi-cantly related to histotype degree，the degree ofdifferentiation，size of tumor and lymph node metastasis (Plt;0.05);Kaplan-Meier survival analysisshowed that the survival time of Gelsolin positive patients was shorter than that of Gelsolinnegative or weakly positive patients (Plt;0.05);Cox regression analysis revealed that lymphnode metastasis and Gelsolin positive expression were the noticeable affective factors on thedeath of the NSCLC patients after surgery. Conclusion: Gelsolin plays an important role in thedevelopment in NSCLC and was associated with transfer and low survival rate in patients with NSCLC，which can be used as an early indicator of NSCLC metastasis and predict- ation of prognosis. 　　Key words: cancer，non-small cell lung;Gelsolin;metastasis;prognosis 　　肺癌作为威胁全世界人类健康的重大疾病，死亡率高。I期非小细胞肺癌(non-smallcell lung can