“smart” continuous glucose monitoring sensors on-line signal processing issuesu201c智能u201d连续葡萄糖监测传感器网络信号处理问题.pdfVIP

Sensors 2010, 10, 6751-6772; doi:10.3390/s100706751 OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Review “Smart” Continuous Glucose Monitoring Sensors: On-Line Signal Processing Issues Giovanni Sparacino, Andrea Facchinetti and Claudio Cobelli * Department of Information Engineering, University of Padova, Via Gradenigo 6/B, 35131 Padova, Italy; E-Mails: gianni@dei.unipd.it (G.S.); andrea.facchinetti@dei.unipd.it (A.F.) * Author to whom correspondence should be addressed; E-Mail: cobelli@dei.unipd.it; Tel.: +39-049-8277803; Fax: +39-049-8277699. Received: 30 May 2010; in revised form: 25 June 2010 / Accepted: 30 June 2010 / Published: 12 July 2010 Abstract: The availability of continuous glucose monitoring (CGM) sensors allows development of new strategies for the treatment of diabetes. In particular, from an on-line perspective, CGM sensors can become ―smart‖ by providing them with algorithms able to generate alerts when glucose concentration is predicted to exceed the normal range thresholds. To do so, at least four important aspects have to be considered and dealt with on-line. First, the CGM data must be accurately calibrated. Then, CGM data need to be filtered in order to enhance their signal-to-noise ratio (SNR). Thirdly, predictions of future glucose concentration should be generated with suitable modeling methodologies. Finally, generation of alerts should be done by minimizing the risk of detecting false and missing true events. For these four