原创力文档a comparative study of mycobacterium avium subsp. avium and mycobacterium avium subsp. hominissuis in experimentally infected pigs鸟型分支杆菌无性系种群的比较研究。.pdfVIP
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a comparative study of mycobacterium avium subsp. avium and mycobacterium avium subsp. hominissuis in experimentally infected pigs鸟型分支杆菌无性系种群的比较研究。
Agdestein et al. BMC Veterinary Research 2012, 8:11
/1746-6148/8/11
RESEARCH ARTICLE Open Access
A comparative study of Mycobacterium avium
subsp. avium and Mycobacterium avium subsp.
hominissuis in experimentally infected pigs
1* 1 1 2 1 1
Angelika Agdestein , Tone B Johansen , Øyvor Kolbjørnsen , Anne Jørgensen , Berit Djønne and Ingrid Olsen
Abstract
Background: Mycobacterium avium subsp. avium (Maa) and Mycobacterium avium subsp. hominissuis (Mah) are
opportunistic pathogens that may infect several species, including humans and pigs. Mah is however more
frequently isolated from pigs than Maa, and it is unclear if this is due to difference in virulence or in exposure to
the two organisms. Clinical isolates of each subspecies were administered perorally to ten domestic pigs,
respectively. The animals were sacrificed at six and 12 weeks after inoculation. At necropsy, macroscopic lesions
were recorded, and tissue samples were collected for mycobacterial culture, IS 1245 real time PCR and
histopathological examination. Culturing was also performed on faecal samples collected at necropsy.
Results: Macroscopic and histopathological lesions were detected in pigs infected with each subspecies, and
bacterial growth and histopathological changes were demonstrated, also in samples from organs without gross
pathological lesions. Six weeks after inoculation, live Mah was detected in faeces, as opposed to Maa. The presence
of live mycobacteria was also more pronounced in Mah infected tonsils. In comparison, the Maa isolate appeared
to have a higher ability of intracellular replication in porcine macrophages compared to the Mah isolate.
Conclusions: The study shows that both sub
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