a core-attachment based method to detect protein complexes in ppi networks基于一种核心的依恋感的方法来检测蛋白复合物在ppi网络.pdfVIP

BMC Bioinformatics BioMed Central Methodology article Open Access A core-attachment based method to detect protein complexes in PPI networks 1 2 1 2 Min Wu , Xiaoli Li* , Chee-Keong Kwoh and See-Kiong Ng Address: 1School of Computer Engineering, Nanyang Technological University, Singapore and 2Institute for Infocomm Research, 1 Fusionopolis Way, Singapore Email: Min Wu - wumi0002@.sg; Xiaoli Li* - xlli@.sg; Chee-Keong Kwoh - asckkwoh@.sg; See- Kiong Ng - skng@.sg * Corresponding author Published: 2 June 2009 Received: 21 October 2008 Accepted: 2 June 2009 BMC Bioinformatics 2009, 10:169 doi:10.1186/1471-2105-10-169 This article is available from: /1471-2105/10/169 © 2009 Wu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: How to detect protein complexes is an important and challenging task in post genomic era. As the increasing amount of protein-protein interaction (PPI) data are available, we are able to identify protein complexes from PPI networks. However, most of current studies detect protein complexes based solely on the observation that dense regions in PPI networks may correspond to prote