复可托治疗小儿反复呼吸道感染疗效及免疫学影响.docVIP

复可托治疗小儿反复呼吸道感染疗效及免疫学影响 　【摘要】 目的 观察复可托对小儿反复呼吸道感染(RRI)者免疫功能的影响。方法 100例RRI患儿随机分为两组，对照组50例予以常规治疗，观察组50例在常规治疗的基础上予以复可托治疗2～3个月，治疗前后分别测定患儿T细胞亚群、免疫球蛋白及补体等指标并观察其变化情况。结果 两组总有效率分别为86%和22.9%，差异有非常显著性(Plt;0.005)，观察组的疗效优于对照组。观察组免疫学指标CD3、CD4、CD4/CD8、IgG、IgA及IgM均明显升高(Plt;0.01或P＜0.05)，CD8较治疗前明显降低(Plt;0.05)。结论 复可托能增强RRI患儿的免疫功能。 【关键词】 反复呼吸道感染；复可托；免疫功能 Curative effect and immunologic effect of Spleen Aminopeptide Oral Lyophilized Powder on infantile repeated respiratory infection 【Abstract】 Objective It is to observe the immunologic effect of Spleen Aminopeptide Oral Lyophilized Powder on infantile repeated respiratory infection (RRI).Methods 100 cases of IRRI were divided into two groups at random.The control group were treated with routine therapy.The treatment group were treated with Spleen Aminopeptide Oral Lyophilized Powder based on routine therapy for 2～3 months.T cell subgroup，immunoglobulin and complements were determined before and after treatment.Results Total effective rates in the treatment group and the control group were 86% and 22.9% respectively.The therapeutic efficacy in treatment group was significantly higher that in control group.In treatment group，immunologic indexes such as CD3，CD4，CD4/CD8，IgG，IgA and IgM increased significantly(Plt;0.05 or P＜0.01) while CD8 decreased (Plt;0.05).Conclusion Spleen Aminopeptide Oral Lyophilized Powder can strengthen immunologic function IRRI. 【Key words】 repeated respiratory infection；Spleen Aminopeptide Oral Lyophilized Powder；immulologic function 反复呼吸道感染(RRI)是儿童时期的常见病，占门诊呼吸道感染的30%，机体的免疫功能低下是发病的主要原因之一。它不仅影响儿童的生活和发育，而且严重影响儿童的身心健康［1］。因此应积极治疗，减少呼吸道感染的发作次数。复可托(脾氨肽口服冻干粉，Spleen Aminopeptide Oral Lyophilized Powder)是从健康新鲜动物脾脏中提取的，主要成分为肽及核苷酸类复合物，含有多种氨基酸和免疫调节因子，具有免疫调控作用［2］。笔者于2002年2月～2006年2月应用复可托治疗小儿反复呼吸道感染98例，观察其临床疗效及对免疫功能的影响，现报告如下。 1 资料与方法 1.1 一般资料 100例均为来自门诊及住院的患儿，诊断均符合全国小儿呼吸道疾病学术会议上拟订的小儿反复呼吸道感染的诊断标准［3］，随机分为两组。观察组50例，男27例，女23例；年龄12个月～12岁，平均(4.4±2.3)岁；每年发作次数为6～14次。对照组48例，男25例，女23例；年龄1～11岁，平均(4.5±2.4)岁；每年发作次数为7～13次。两组病