新洁尔灭及复方新诺明治疗新生儿脓疱疮疗效观察.doc

新洁尔灭及复方新诺明治疗新生儿脓疱疮疗效观察 　【关键词】 新洁尔灭;复方新诺明;新生儿脓疱疮 　　［摘要］目的: 探讨新洁尔灭溶液药浴加复方新诺明粉末外敷治疗新生儿脓疱疮的疗效。 方法: 将新生儿脓疱疮82例随机分为治疗组和对照组，治疗组45例采用0.01%新洁尔灭溶液全身沐浴，然后用复方新诺明粉末调湿外敷;对照组37例采用百多邦软膏局部涂擦。 结果: 治疗组有效率95.56%，对照组有效率56.76%，差异有统计学意义（χ 2 =17.84，Plt;0.01）;住院时间治疗组明显短于对照组（t=18.129，Plt;0.05）。 结论: 新洁尔灭药浴加复方新诺明粉末外敷治疗新生儿脓疱疮效果明显优于百多邦软膏局部涂擦，未见明显不良反应。 　　［关键词］ 新洁尔灭;复方新诺明;新生儿脓疱疮 　　An observation of therapeutic effect of bromogeramine and SMZ-TMP in treating impetigo neonatorum 　　［Abstract］ Objective:To explore the therapeutic effect of bromogeramine solution in medicated bath in addtion to external application of SMZ-TMP powder in treating impetigo neonayorum.Methods:Eighty-two patients were divided randomly into treatment group and control group.Forty-five pa-tients were treated with medicated bath of0.01%bromogeramine solution，and then applicated externally with SMZ-TMP powder.Thirty-seven pa-tients were applicated with mupirocin ointment.The therapeutic effect and length of stay were observed in both groups.Results:The effective power was95.56%in treatment group，and56.76%in control group.The difference was significant in statistics（χ 2 =17.84，Plt;0.01）.Hospital days were shorter in treatment group than in control group.The difference was significant in statistics（t=18.129，Plt;0.05）.Conclusions:There is no evidence of poison and adverse reaction in our study of medicated bath of bromogeramine solution in addition to external application of SMZ- TMP powder in treating impetigo neonayorum.The therapeutic effect surpass that of mupirocin ointment. 　　［Key words］Bromogeramine;SMZ-TMP;Impetigo neonayorum 　　新生儿脓疱疮是新生儿的一种常见急性传染性皮肤病，该病传染性强、易流行，发病率较高，如处理不当可并发败血症、肺炎或脑膜炎等。该病的治疗药物及治疗方法报道甚多，但未见新洁尔灭药浴联合复方新诺明粉末外敷用于该病治疗的报道。我院新生儿室采用0.01%新洁尔灭溶液全身药浴加复方新诺明粉末外敷治疗，取得良好效果，现报道如下。 　　1 资料与方法 　　1.1 临床资料 　　2003年1月～2005年12月共收治新生儿脓疱疮患儿82例，随机分为治疗组45例，对照组37例，两组患儿在性别、年龄、体重、病情、黄疸程度等方面差异无统计学意义，具有可比性，见表1。在患儿入院时详细询问父母家族对磺胺类药的过敏史，有过敏史者不列入本资料观察范围。 　　表1 两组一般资料比较（略） 　　1.2 方法 　　1.2.1 治疗方法 治疗组采用5%的新洁尔灭溶液20mL加温开水10000mL配成浓