无机陶瓷膜超滤精制连花清瘟颗粒工艺探究.doc

无机陶瓷膜超滤精制连花清瘟颗粒工艺探究 　作者：魏学君，陈占立，孙长荣，范文成，石润波 【摘要】 目的在无机陶瓷膜精制连花清瘟颗粒过程中，考察不同孔径的膜对该体系的适用性，并进行膜过程优化设计。方法以连花清瘟水提液为研究对象，测定了3种不同孔径膜及不同操作参数下对膜通量及有效成分含量的变化。结果50 nm膜的膜通量最大，甘草酸及绿原酸转移率最高，最佳大生产过滤条件为操作压差为0.08～0.12 MPa，过滤温度50～60℃,膜面流速3.0 m/s；当过滤液浓缩到原液体积1/10时，加入相同体积的水，有效成分转移率达80%以上，即可结束过滤。采用强酸、强碱交替清洗，膜通量可恢复99%以上。结论采用无机陶瓷膜超滤技术精制连花清瘟颗粒是可行的，并为陶瓷膜分离技术应用于其它中药水提液的精制提供了依据。 【关键词】 连花清瘟颗粒； 陶瓷膜超滤； 精制； 分离技术 ChinaAbstract:ObjectiveTo observe the effect of the different bore diameter membranes on the parameters of technologies of Lianhua Qingwen Granules and to optimize the process of membrane filtration. Methods Three different membranes were tested under different parameters of operation to observe the changes in membrane flux and the content of effective components by Lianhua Qingwen Granules. Results The membrane with the 50nm had the great flux , the transfer rates of glycyrrhizin and chlorogenic acid were the highest. The optimum conditions were that the operation differential pressure was 0.08～0.12 MPa, the operation temperature was 50～60℃, and the membrane surface flow rate was 3. 0 m/s. When the volume of filtration solution was condensed to 1/10 of former, entering the same volume water into it, and when the effective components transfer late reached 80%，the filtration was finished. Using the strong acid and strong alkali to wash it in turn ,the flux could arrice above 99%. Conclusion A good result can be obtained by adopting the technology of Inorganic Pottery Membranes microfiltration to refine Lianhua Qingwen Granule and This provides the foundation for the application of pottery membrane microfiltration in the refinement of water extraction of other Chinese medicines. 　　Key words:Lianhua Qingwen Granule; Pottery membrane microfiltration; Refinement; Isolation technology 　　连花清瘟颗粒是石家庄以岭药业股份有限公司新产品,为复方中药制剂，由金银花、板蓝根、红景天、甘草等13味中药组成，具有清瘟解毒宣肺泻热的功效，用于治疗流行性感冒属热证袭肺证，已被广泛应用于临床。 陶瓷膜超滤技术在中药提取分离应用日益增多，陶瓷膜超滤是根据膜孔径大小特征对中药提取液中各药效组方依分子大小进行分离过程［1］；本文采用陶瓷膜分离技术对连花清瘟颗粒精制工艺进行研究，以膜通量、有效成分透过率为指标，综合考察不同孔