消栓降脂丸对急性血淤模型大鼠血液流变学影响对照探究.docVIP

消栓降脂丸对急性血淤模型大鼠血液流变学影响对照探究 　 作者：杨诗杰， 项岚， 王娜 ， 蔡定彬， 苏汝好 【关键词】 消栓降脂丸；,,急性血淤模型；,,血液流变学；,,血小板最大聚集率, 　　摘要：目的探讨消栓降脂丸对急性血淤模型大鼠血液流变学、血小板聚集的影响，并以复方丹参片对照。方法用SAS统计软件把60只大鼠随机分为6组，消栓降脂丸预防给药14 d，皮下注射肾上腺素，冰水浸泡建造急性血淤模型，采血测定血液流变学和血小板聚集指标。结果消栓降脂丸能明显降低急性血淤模型组大鼠全血黏度、全血还原黏度、血浆黏度、红细胞压积、红细胞聚集指数，纤维蛋白原的水平，升高红细胞变形指数，抑制血小板聚集，在改善某些指标方面优于复方丹参组，各组之间显示出剂量依赖性。结论消栓降脂丸有明显的改善急性血淤模型大鼠血液流变学和抗血小板聚集的作用，能改善血液的高凝状态，对冠心病及其相关性疾病有一定的预防治疗作用。 　　关键词：消栓降脂丸； 急性血淤模型； 血液流变学； 血小板最大聚集率 　　　Abstract：ObjectiveTo observe and compare the effects of XSJZW with FFDSP on the hemorheology and platelet aggregation in acute bloodstasis model rats. Methods60 SD rats were divided into 6 groups at random by SAS, the rats were pretreated with drug or 0.3％CMC by lavage respectively according to the regulation， soaked after injection s.c with 0.08mg/100g adrenine into ice water for 5min to prepare rat model of acute blood stasis. Then the parameters of hemorheology and platelet aggregation were determined. ResultsThe XSJZW groups could obviously decrease the levels of blood viscosity high 、low shears , blood reduce viscosity high 、low shears, hematocrit , index of erythrocyte aggregation , fibrinogen(Plt;0.01 or Plt;0.05),and increase those of index of erythrocyte deformability (Plt;0.05), inhibit platelet aggregation，improve some parameters, XSJZW groups were better than FFDSP(Plt;0.05),the dosedependence was observed among the XSJZW groups. ConclusionThe XSJZW groups can significantly improve hemorheology and hypercoagulabale state of blood and inhibit platelet aggregation in acute bloodstasis model rats， and is beneficial to prevent and treat the development of coronary artery disease and its complications. 　　Key words：XSJZW； Acute Blood Stasis Model； Hemorheology; Platelet Aggregation 　　消栓降脂丸是我院方剂，临床应用十余年来，其对高血脂症、动脉粥样硬化、冠心病、脑中风等心血管性疾病有很好的预防治疗作用［1］。卢大雷等［2］曾观察了消栓降脂丸对TIA病人血小板活化功能及血浆纤溶酶活性的影响，我们报道过其对高脂血症大鼠血液流变学的影响［3］ 。本研究进一步探讨消栓降脂丸对急性血淤模型大鼠血液流变学和血小板聚集的影响。 　　1 材料与方法 　　1.1 材料 　　1.1.1 药品与试剂 消栓降脂丸（XSJZW），规格：90 g/瓶，每克相当于原药材0.9 g，开封市医学科