白芍总苷增强高脂血症-胰岛素抵抗大鼠胰岛素敏感性及降血脂作用.doc

白芍总苷增强高脂血症-胰岛素抵抗大鼠胰岛素敏感性及降血脂作用 　 作者：郑琳颖，潘竞锵，吕俊华 【摘要】 　　目的观察白芍总苷对高脂血症大鼠胰岛素敏感性和血脂作用。方法将实验鼠分正常对照组和胰岛素抵抗大鼠造模组，后者连续8周的高脂饲料喂饲，建立胰岛素抵抗大鼠模型后，随机分为模型组、二甲双胍组及白芍总苷高、低剂量组，观察上述药物对大鼠胰岛素、血糖、血脂含量和胰岛素敏感性的影响。结果二甲双胍和白芍总苷高剂量组能明显降低大鼠血清胰岛素含量和胰岛素抵抗指数（Plt;0.01），提高胰岛素敏感指数（Plt;0.01）；二甲双胍和白芍总苷高低剂量组均能明显降低大鼠的TC, FFA, TG, LDL-C水平(Plt;0.05或Plt;0.01)，均可增加HDL-C含量(Plt;0.05)；二甲双胍不影响空腹血糖（FBG）(Pgt;0.05)，却降低口服糖耐量试验2 h血糖（OGTT-2hBG）(Plt;0.05)，但白芍总苷高低剂量组对FBG和OGTT-2hBG作用，则差异均未见显著性(Pgt;0.05)。结论 白芍总苷能增强高脂饲养诱导高脂血症-胰岛素抵抗大鼠胰岛素敏感性，降低高胰岛素血症和血脂含量，其降低血脂效应可能是改善胰岛素敏感性的主要作用机制。 【关键词】 白芍总苷 二甲双胍 高脂血症 胰岛素抵抗 大鼠 　　Abstract：ObjectiveTo investigate total glucosides of paeong (TGP) on insulin sensitivity and blood lipid in insulin resistant rats induced by high fat diet and its possible mechanism. MethodsThe rats were divided into normal group and test groups. The rats in test groups were fed with high fat diet for 8 weeks to induce the insulin resistant model. After the model was esthblished, the rats were divided into four groups randomly, the model group, the metformin group, the high-dose TGP group and the low-dose TGP group. All the rats were checked their levels of insulin, blood sugar, blood fat and counted the value of insulin sensitivity. ResultsCompared with the model group, the levels of insulin and IRI in metformin and high-dose TGP groups were reduced obviously （Plt;0.01）,and the ISI were increased obviously （Plt;0.01）.All the three drug-used groups could reduce the levels of TC, FFA, TG and LDL-C (Plt;0.05 or Plt;0.01), and increase the concentration of HDL-C (Plt;0.05). Metformin did not affect FBG (Pgt;0.05), but reduced OGTT-2hBG (Plt;0.05). Both high-dose TGP and low-dose TGP could affect FBG and OGTT-2hBG, but the difference were not significant (Pgt;0.05). ConclusionTGP could enhance insulin sensitivity hyperlipemic and insulin resistant rats’ in induced by high fat diet, and reduce the levels of TC and TG, which maybe the most possible effective mechanism of improving insulin sensitivity by TGP. 　　Key words