空腹血糖正常冠心病患者糖代谢状况及血PAI-1，hsCRP，HbA1c及.docVIP

空腹血糖正常冠心病患者糖代谢状况及血PAI-1，hsCRP，HbA1c及 　 作者：李嘉，陈鹏，吴连拼，杨鹏麟 【摘要】 　　目的 ：调查空腹血糖正常的冠心病患者糖代谢状况，探讨冠心病合并糖耐量减低患者血浆纤溶酶原激活物抑制物1(PAI-1)、高敏C反应蛋白（hs-CRP）、糖化血红蛋白（HbA1c）水平与冠脉病变的关系。方法：对冠脉造影确诊的226例冠心病患者行口服葡萄糖耐量试验，据结果分成糖耐量正常(NGT)组，糖耐量减低(IGT)组和2型糖尿病(T2DM)组，分析糖代谢状况，测定三组的血PAI-1，hs-CRP，HbA1c水平和冠脉病变积分。结果：共发现糖代谢异常者120例(53.1%) ；血PAI-1，hs-CRP，HbA1c水平和冠脉病变积分在IGT 和T2DM组比NGT组明显升高(P lt;0.05) ；相关分析显示，冠心病合并IGT组血PAI-1，hs-CRP，HbA1c水平和冠状动脉病变积分呈正相关，相关系数分别为r =0.6082(P lt;0.01)、0.4443(P lt;0.05)、0.6327(P lt;0.01)。结论 ：空腹血糖正常的冠心病患者糖代谢异常发生率高；冠心病合并IGT者冠脉病变严重，多支冠脉病变发生率高，病变呈弥漫性狭窄；血浆PAI-1，hs-CRP，HbA1c水平和冠状动脉病变严重程度有关。 【关键词】 冠状动脉疾病 糖耐量减低 纤溶酶原激活物抑制物1 高敏C反应蛋白 糖化血红蛋白 冠状动脉造影 　　Abstract: Objective: To investigate the glucose metabolism status in coronary heart disease patients with normal fasting blood sugar levels and research on the relationship between the levels of plasminogen activator inhibitor-1 (PAI-1)， high-sensitive g-reactive protein (hs-CRP)， glycosylated hemoglobin a1c (HbA1c) and coronary artery lesions in coronary heart disease patients with abnormal glucose tolerance. Methods: OGTT was performed in 226 cases who were confirmed coronary heart disease with coronary angiography，according to the oral glucose tolerance test (OGTT) results、Patients were divided into 3 groups， which included NGT group with normal fasting blood sugar level， IGT group with impaired glucose tolerance， and T2DM group with type 2 diabetes mellitus. PAI-1， hs-CRP， HbA1c were checked and the coronary narrow degree integral was calculated in all of the patients. Results: 120 cases of abnormal glucose metabolism (53.1%) were found. Plasma PAI-1、hs-CRP、HbA1c levels and coronary narrow degree integrals were higher in both IGT group and T2DM group than that in NGT group (P lt;0.05). Correlative analysis showed that plasma PAI-1、hs-CRP、HbA1c levels in coronary heart disease cases with IFG were positively correlated with the coronary narrow degree integrals(Gensini scores). Correlation coefficient was r =0.6082 (P lt;0.01)，0.4443 (P