病毒学抑制情况.DOC

三种不同初始标准抗病毒方案治疗育龄女性艾滋病的疗效分析 蓝珂，李勇 （广西艾滋病诊疗质控中心　广西壮族自治区龙潭医院 ，广西 柳州 545005） 摘要目的克立芝（LPV/r）或依非韦伦（EFV）或奈韦拉平（NVP）联合两个核苷类反转录酶抑制剂（NRTIs）初始标准方案治疗育龄滋病病毒（HIV）感染者/艾滋病（AIDS）病人（简称HIV/AIDS）的。方法开始、48周、96周、144周血浆HIV RNA载量、CD4+T淋巴细胞（简称CD4细胞）计数结果例。病毒学疗效： EFV组、NVP组、LPV/r组的病毒抑制率治疗48周时分别为86.0%、87.6%、89.2%；96周时分别为91.5%，84.1%，94.5%；192周时，分别为93.3%，93.2%，92.7%。各组均可达到较高的病毒抑制率，组间无明显差异（P=0.601P=0.286）。免疫学疗效：治疗随访1周，三组的CD4细胞都有明显增加，其中LPV/r组的CD4增长值明显高于EFV、NVP组342.71 ± 176.94）个/μL, EFV组较基线平均增长了310.24 ± 194.63）个/μL, NVP组较基线平均增长258.09 ± 177.22）个/μL，三组差异具有显著性（P0.001）/μL, 192周时LPV/r组的CD4增长也优于EFV或NVP组。结论 三种抗病毒方案对育龄女性HIV/AIDS的血浆HIV抑制率无差异，含LPV/r组的方案对CD4细胞的提升方面占据优势。 关键词：艾滋病病毒；育龄女性；初治；抗病毒方案；疗效分析 Efficacy analysis of three standard antiretroviral therapies in treatment of AIDS in women of childbearing age Lan Ke, Qin Shanfang, Huang Wei, Lv Qing, Meng Zhihao, Li Yong Guangxi AIDS Diagnosis and Treatment Quality Control Center, The Guangxi Zhuang Autonomous Region Longtan Hospital, Liuzhou 545005, China Abstract:Objective: To study the efficacy of three initial standard antiretroviral therapy used by HIV infected women of childbearing age, including Lopinavir/Ritonavir (LPV/r) or efavirenz (EFV) or nevirapine (NVP) combined with two nucleoside reverse transcriptase inhibitors (NRTIs). Methods: From January 2006 to December 2015 in Guangxi Province, follow-up data about HIV infected women of childbearing age using standard antiretroviral therapy in continuous treatment for more than 4 years were collected, including plasma HIV RNA load and CD4+T lymphocyte count before therapy and at the 48 weeks, 96 weeks, 144 weeks and 192 weeks after the antiviral treatment. Results: A total of 1035 HIV infected women of childbearing age were enrolled with 345 cases in EFV group, NVP group and LPV/r group respectively. In terms of virological efficacy, the rate of virus inhibition in group EFV, group NVP and group LPV/r were 86.0%, 87.6% and 89.2% respectively at 48 weeks; 91.5%, 84.1% and 94.5% at 96 weeks; 93.3%, 93.2%