米氮平及文拉法辛治疗抑郁症对照探究.docVIP

米氮平及文拉法辛治疗抑郁症对照探究 　【关键词】 米氮平；,,文拉法辛；,,抑郁症 　　【摘要】 目的 探讨米氮平与文拉法辛治疗抑郁症的疗效与不良反应。方法 将100例抑郁症患者随机分为米氮平组和文拉法辛组。于治疗1，2，6w末采用汉密尔顿抑郁量表和副反应量表评定临床疗效与不良反应。 结果 治疗2w末时，文拉法辛组减分率较米氮平组下降明显，差异有显著性(t=2.61,P＜0.05）；治疗6w末两组减分率无显著性差异(t=0.21,P＞0.05)。治疗结束时米氮平组显效率64%，有效率88%；文拉法辛组显效率60%，有效率80%，两组疗效无显著性差异。两组不良反应均较轻微，且差异无显著性(P＞0.05)。结论 米氮平与文拉法辛的抗抑郁疗效肯定，不良反应轻微。 　　【关键词】 米氮平； 文拉法辛； 抑郁症 　　Controlled study of mirtazapine vs. venlafaxine in the treatment of depression 　　 　　【Abstract】 Objective To explore efficacies and side effects of mirtazapine vs. venlafaxine in the treatment of depression. Methods 100 patients with depression were randomly divided into mirtazapine and venlafaxine group. Efficacies and side effects were assessed with the Hamilton Depression Scale(HADS) and Treatment Emergent Symptom Scale(TESS) at the ends of the 1st, 2nd and 6th week of treatment. Results At the end of the 2nd week, scorereducing rate decreased more significantly in the venlafaxine than in the mirtazapine group, and difference was significant(Plt;0.05); at the end of the 6th week, there was no significant difference in scorereducing rate between the 2 groups(Pgt;0.05).After treatment, effectual and effective rates of the mirtazapine group were 64% and 88% and those of the venlafaxine 60% and 80% respectively, which showed no significant difference. Side effects of both 2 groups were milder and had no significant difference(Pgt;0.05). Conclusion Both mirtazapine and venlafaxine have better efficacy and milder side effect in the treatment of depression. 　　【Keywords】 Mirtazapine; venlafaxine; depression 　　抑郁症是一种严重危害人们心身健康的精神疾病，但直至目前对于抑郁症的治疗一直没有大的进展，在很大程度上影响了患者的治疗依从性。作者应用米氮平和文拉法辛对抑郁症进行了临床治疗观察，现将结果报告如下。 　　1 对象与方法 　　1.1对象 　　选取我院门诊100例抑郁症患者为研究对象，入组标准:(1)符合《中国精神障碍分类与诊断标准》第3版(CCMD3)抑郁症诊断标准；(2)汉密尔顿抑郁量表（HAMD）评分≥18分；(3)排除器质性疾病、药物过敏者和妊娠期、哺乳期妇女。随机将100例患者分为两组，其中米氮平组50例，男26例，女24例；平均年龄39.8±18.7a；病程1～36mo，平均5.3±5.1mo。文拉法辛组50例，男22例，女28例；平均年龄38.2±16.7a；病程1.5～38mo，平均5.2±4.9mo。 　　以上各项两组差异无显著性(Pgt;0.05)。 　　1.2 方法 　　1.2.1 治疗 　　入组前停用原