绿激光前列腺汽化术对患者血管内皮功能影响及其围手术期安全性评.docVIP

绿激光前列腺汽化术对患者血管内皮功能影响及其围手术期安全性评 　 作者：雒向宁，王禾，杨波，刘贺亮，李欣，秦荣良，袁建林，翟振波，马建军 【关键词】 内皮缩血管肽1；前列腺增生；外科手术；绿激光；冠状动脉疾病 　　Effect of greenlight photoselective vaporization on vascular endothelial function of patients with benign prostatic hyperplasia and its safety during perioperative period 　　【Abstract】 AIM: To investigate the relationship between greenlight photoselective vaporization (PVP) and the stroke of coronary heart disease (CHD) and access the safety of PVP for benign prostatic hyperplasia (BPH) combined with CHD during perioperative period． METHODS: Seventytwo patients underwent surgical treatment: openoperation (n=34), PVP (n=38). All 72 patients were divided into 2 groups according to whether BPH was combined with CHD or not(CHD group and nonCHD group). The serum level of ET1 was measured by ELISA before and after treatment,respectively. RESULTS: The levels of ET1 in CHD groups［OP group vs PVP group: (83.19±12.83) vs (85.98±10.19) ng/L］ before operation showed no significant difference（t＝0.777,Pgt;0.05）;One day after operation, the level of serum ET1 of OP group［(123.01±25.98) ng/L］ was significantly higher than that of PVP group［(92.74±10.40) ng/L］(t＝2.823, Plt;0.01), and 2d after operation, the level of serum ET1 of OP group［(114.1±28.22) ng/L］ was still significantly higher than that of PVP group［(90.12±10.22) ng/L］ （t＝4.678, Plt;0.01）. The levels of ET1 of nonCHD group ［OP group vs PVP groups: (49.74±9.23) vs (48.10±9.10) ng/L］ before operation showed no significant difference(t＝0.478,Pgt;0.05); 1d after operation, the level of serum ET1 of OP group［(68.67±12.55) ng/L］ was significantly higher than that of PVP group［(53.89±9.70) ng/L］(t=4.370, Plt;0.01), and 2 d after operation, the level of serum ET1 of OP group［(114.1±28.22) ng/L］ was still significantly higher than that of PVP group［(90.12±10.22) ng/L］ （t＝2.614,Plt;0.05）. CONCLUSION: There is a significantly damaged vascular endothelial function after OP in BPH patients, especially in BPH patients complicated w