a new permutation strategy of pathway-based approach for genome-wide association study一个新的排列pathway-based方法全基因组关联研究的策略.pdfVIP

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a new permutation strategy of pathway-based approach for genome-wide association study一个新的排列pathway-based方法全基因组关联研究的策略.pdf

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a new permutation strategy of pathway-based approach for genome-wide association study一个新的排列pathway-based方法全基因组关联研究的策略

BMC Bioinformatics BioMed Central Methodology article Open Access A new permutation strategy of pathway-based approach for genome-wide association study 1,2,3 3 2 3,5 Yan-Fang Guo , Jian Li , Yuan Chen , Li-Shu Zhang and Hong-Wen Deng*2,3,4,5 Addresses: 1School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, PR China, 2Institute of Molecular Genetics, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, PR China, 3Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri - Kansas City, Kansas City, MO 64108, USA, 4Center of Systematic Biomedical Research, Shanghai University of Science and Technology, Shanghai 200093, PR China and 5College of Life Sciences and Engineering, Beijing Jiao Tong University, Beijing 100044, PR China E-mail: Yan-Fang Guo - guoyanfang@; Jian Li - lijian@; Yuan Chen - miding_720@; Li-Shu Zhang - lshzhang@; Hong-Wen Deng* - dengh@ *Corresponding author Published: 18 December 2009 Received: 10 June 2009 Accepted: 18 December 2009 BMC Bioinformatics 2009, 10:429 doi: 10.1186/1471-2105-10-429 This article is available from: /1471-2105/10/429 © 2009 Guo et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Recent