原创力文档a novel multifunctional oligonucleotide microarray for toxoplasma gondii一种新型多功能寡核苷酸微阵列刚地弓形虫.pdfVIP
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Bahl et al. BMC Genomics 2010, 11:603
/1471-2164/11/603
RESEARCH ARTICLE Open Access
A novel multifunctional oligonucleotide
microarray for Toxoplasma gondii
1 2 3,7 4 5 6
Amit Bahl , Paul H Davis , Michael Behnke , Florence Dzierszinski , Manjunatha Jagalur , Feng Chen ,
6 3,8 5 6*
Dhanasekaran Shanmugam , Michael W White , David Kulp , David S Roos
Abstract
Background: Microarrays are invaluable tools for genome interrogation, SNP detection, and expression analysis,
among other applications. Such broad capabilities would be of value to many pathogen research communities,
although the development and use of genome-scale microarrays is often a costly undertaking. Therefore, effective
methods for reducing unnecessary probes while maintaining or expanding functionality would be relevant to
many investigators.
Results: Taking advantage of available genome sequences and annotation for Toxoplasma gondii (a pathogenic
parasite responsible for illness in immunocompromised individuals) and Plasmodium falciparum (a related parasite
responsible for severe human malaria), we designed a single oligonucleotide microarray capable of supporting a
wide range of applications at relatively low cost, including genome-wide expression profiling for Toxoplasma, and
single-nucleotide polymorphism (SNP)-based genotyping of both T. gondii and P. falciparum. Expression profiling of
the three clonotypic lineages dominating T. gondii populations in North America and Europe provides a first
comprehensive view of the parasite transcriptome, revealing that ~49% of all annotated genes are expressed in
parasite
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