a polymorphism in the 3 untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk a nested case-control study的多态性基因的3 端非翻译区编码前列腺素内过氧化物合酶2是不与乳腺癌风险增加有关嵌套病例对照研究.pdfVIP

Available online /content/9/1/R3 Vol 9 No 1 Open Access Research article A polymorphism in the 3 untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study 1,2 3 2,4 1,2 David G Cox , Julie Buring , Susan E Hankinson and David J Hunter 1Program in Genetic and Molecular Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA 2Channing Laboratory, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA 3Division of Preventive Medicine, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, 900 Commonwealth Avenue, Boston, MA 02215, USA 4Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA Corresponding author: David G Cox, dcox@ Received: 26 Oct 2006 Revisions requested: 13 Nov 2006 Revisions received: 16 Nov 2006 Accepted: 10 Jan 2007 Published: 10 Jan 2007 Breast Cancer Research 2007, 9:R3 (doi:10.1186/bcr1635) This article is online at: /content/9/1/R3 © 2007 Cox et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Prostaglandins are integral components in the Results The rs5275 polymorphism in the 3 untranslated region cellular response