原创力文档a potential role for intragenic mirnas on their hosts interactome基因内的潜在作用microrna在宿主的interactome.pdfVIP
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a potential role for intragenic mirnas on their hosts interactome基因内的潜在作用microrna在宿主的interactome
Hinske et al. BMC Genomics 2010, 11:533
/1471-2164/11/533
RESEARCH ARTICLE Open Access
A potential role for intragenic miRNAs on their
hosts’ interactome
1,2* 3 4,5 2
Ludwig Christian G Hinske , Pedro AF Galante , Winston P Kuo , Lucila Ohno-Machado
Abstract
Background: miRNAs are small, non-coding RNA molecules that mainly act as negative regulators of target gene
messages. Due to their regulatory functions, they have lately been implicated in several diseases, including
malignancies. Roughly half of known miRNA genes are located within previously annotated protein-coding regions
(intragenic miRNAs”). Although a role of intragenic miRNAs as negative feedback regulators has been speculated,
to the best of our knowledge there have been no conclusive large-scale studies investigating the relationship
between intragenic miRNAs and host genes and their pathways.
Results: miRNA-containing host genes were three times longer, contained more introns and had longer 5’ introns
compared to a randomly sampled gene cohort. These results are consistent with the observation that more than
60% of intronic miRNAs are found within the first five 5’ introns. Host gene 3’-untranslated regions (3’-UTRs) were
40% longer and contained significantly more adenylate/uridylate-rich elements (AREs) compared to a randomly
sampled gene cohort. Coincidentally, recent literature suggests that several components of the miRNA biogenesis
pathway are required for the rapid decay of mRNAs containing AREs. A high-confidence set of predicted mRNA
targets of intragenic miRNAs also shared many of these features with the host genes. Approximately 20% of
intragenic miRNAs were predicted to target their host mRNA transcript. Further, KEGG pa
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