a role for snx5 in the regulation of macropinocytosis一个角色snx5 macropinocytosis的规定.pdfVIP

BMC Cell Biology BioMed Central Research article Open Access A role for SNX5 in the regulation of macropinocytosis †1 2 2 2 Jet Phey Lim , Jack TH Wang* , Markus C Kerr , Rohan D Teasdale and Paul A Gleeson*1 1 Address: The Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria 3010, Australia and 2Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia Email: Jet Phey Lim - j.lim20@.au; Jack TH Wang * - t.wang@.au; Markus C Kerr - m.kerr@.au; Rohan D Teasdale - R.Teasdale@.au; Paul A Gleeson* - pgleeson@.au * Corresponding authors †Equal contributors Published: 14 October 2008 Received: 3 June 2008 Accepted: 14 October 2008 BMC Cell Biology 2008, 9:58 doi:10.1186/1471-2121-9-58 This article is available from: /1471-2121/9/58 © 2008 Lim et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The mechanisms and components that regulate macropinocytosis are poorly understood. Here we have investigated the role of sorting nexin 5 (SNX5) in the regulation of macr