原创力文档a signature-based method for indexing cell cycle phase distribution from microarray profiles基于签名的方法索引细胞周期阶段分布从微阵列配置文件.pdfVIP
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a signature-based method for indexing cell cycle phase distribution from microarray profiles基于签名的方法索引细胞周期阶段分布从微阵列配置文件
BMC Genomics BioMed Central
Methodology article Open Access
A signature-based method for indexing cell cycle phase distribution
from microarray profiles
1,2 1 1 2
Hideaki Mizuno* , Yoshito Nakanishi , Nobuya Ishii , Akinori Sarai and
Kunio Kitada1
Address: 1Kamakura Research Laboratories, Chugai Pharmaceutical Co Ltd, Kamakura, Kanagawa, Japan and 2Department of Biosciences and
Bioinformatics, Kyushu Institute of Technology, Iizuka, Fukuoka, Japan
Email: Hideaki Mizuno* - mizunohda@chugai-pharm.co.jp; Yoshito Nakanishi - nakanishiyst@chugai-pharm.co.jp;
Nobuya Ishii - ishiinby@chugai-pharm.co.jp; Akinori Sarai - sarai@bse.kyutech.ac.jp; Kunio Kitada - kitadakno@chugai-pharm.co.jp
* Corresponding author
Published: 30 March 2009 Received: 21 October 2008
Accepted: 30 March 2009
BMC Genomics 2009, 10:137 doi:10.1186/1471-2164-10-137
This article is available from: /1471-2164/10/137
© 2009 Mizuno et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: The cell cycle machinery interprets oncogenic signals and reflects the biology of
cancers. To date, various methods for cell cycle phase estimation such as mitotic index, S phase
fraction, a
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