原创力文档a study of antimicrobial activity, acute toxicity and cytoprotective effect of a polyherbal extract in a rat ethanol-hcl gastric ulcer model抗菌活性的研究、急性毒性和cytoprotective polyherbal提取的效果一只老鼠ethanol-hcl胃溃疡模型.pdfVIP
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a study of antimicrobial activity, acute toxicity and cytoprotective effect of a polyherbal extract in a rat ethanol-hcl gastric ulcer model抗菌活性的研究、急性毒性和cytoprotective polyherbal提取的效果一只老鼠ethanol-hcl胃溃疡模型
Haule et al. BMC Research Notes 2012, 5:546
/1756-0500/5/546
RESEARCH ARTICLE Open Access
A study of antimicrobial activity, acute toxicity
and cytoprotective effect of a polyherbal extract
in a rat ethanol-HCl gastric ulcer model
1 1* 1 1
Emmanuel E Haule , Mainen J Moshi , Ramadhani SO Nondo , Dennis T Mwangomo
and Rogasian LA Mahunnah2
Abstract
Background: The decoction of the aerial parts of Rhynchosia recinosa (A.Rich.) Bak. [Fabaceae] is used in
combination with the stem barks of Ozoroa insignis Del. (Anacardiaceae), Maytenus senegalensis (Lam.) Excell.
[Celastraceae] Entada abyssinica Steud. ex A.Rich [Fabaceae] and Lannea schimperi (Hochst.)Engl. [Anacardiaceae] as
a traditional remedy for managing peptic ulcers. However, the safety and efficacy of this polyherbal preparation has
not been evaluated. This study reports on the phytochemical profile and some biological activities of the individual
plant extracts and a combination of extracts of the five plants.
Methods: A mixture of 80% ethanol extracts of R. recinosa, O. insignis, M. senegalensis, E. abyssinica and L. schimperi
at doses of 100, 200, 400 and 800 mg/kg body wt were evaluated for ability to protect Sprague Dawley rats from
gastric ulceration by an ethanol-HCl mixture. Cytoprotective effect was assessed by comparison with a negative
control group given 1% tween 80 in normal saline and a positive control group given 40 mg/kg body wt
pantoprazole. The individual extracts and their combinations were also tested for antibacterial activity against four
Gram negative bacteria; Escherichia coli (ATCC 25922), Salmonella typhi (NCTC 8385), Vibrio cholerae (clinical isolate),
and Klebsiella pneumoniae (clinical isolate) using the microdilu
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