a summarization approach for affymetrix genechip data using a reference training set from a large, biologically diverse database使用一个参考的总结方法affymetrix genechip数据从大训练集,生物多样性数据库.pdfVIP
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a summarization approach for affymetrix genechip data using a reference training set from a large, biologically diverse database使用一个参考的总结方法affymetrix genechip数据从大训练集,生物多样性数据库
BMC Bioinformatics BioMed Central
Methodology article Open Access
A summarization approach for Affymetrix GeneChip data using a
reference training set from a large, biologically diverse database
1 2 3 1
Simon Katz , Rafael A Irizarry , Xue Lin , Mark Tripputi and
Mark W Porter*1
Address: 1Gene Logic Inc., 610 Professional Dr, Gaithersburg, MD, 20876, USA, 2Department of Biostatistics, Johns Hopkins Bloomberg School
of Health, 615 N Wolfe St, Baltimore, MD, 21205, USA and 3Department of Applied Mathematics and Statistics, Johns Hopkins. University, 302
Whitehead Hall, 3400 North Charles Street, Baltimore, MD, 21218, USA
Email: Simon Katz - skatz@; Rafael A Irizarry - rafa@; Xue Lin - xlin@;
Mark Tripputi - mtripputi@; Mark W Porter* - mporter@
* Corresponding author
Published: 23 October 2006 Received: 11 July 2006
Accepted: 23 October 2006
BMC Bioinformatics 2006, 7:464 doi:10.1186/1471-2105-7-464
This article is available from: /1471-2105/7/464
© 2006 Katz et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Many of the most popular pre-processing methods for Affymetrix expression
arrays, such as RMA, gcRMA, and PLIER, simultaneously analyze data across a set of predetermined
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