原创力文档aberrant expression of id2 protein and its correlation with ebv-lmp1 and p16(ink4a) in classical hodgkin lymphoma in chinaid2蛋白的异常表达及其相关ebv-lmp1和p16(ink4a)在中国古典霍奇金淋巴瘤.pdfVIP
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aberrant expression of id2 protein and its correlation with ebv-lmp1 and p16(ink4a) in classical hodgkin lymphoma in chinaid2蛋白的异常表达及其相关ebv-lmp1和p16(ink4a)在中国古典霍奇金淋巴瘤
BMC Cancer BioMed Central
Research article Open Access
Aberrant Expression of ID2 protein and its correlation with
EBV-LMP1 and P16(INK4A) in Classical Hodgkin Lymphoma in
China
† † † †
Po Zhao , Yali Lu , Lin Liu and Mei Zhong*
Address: Department of Pathology, Chinese Peoples Liberation Army (PLA) General Hospital, 28 Fuxing Road, Beijing 100853, PR China
Email: Po Zhao - zhaopo@301; Yali Lu - lyl301@263.net; Lin Liu - liulin@263.net; Mei Zhong* - zhongmei@
* Corresponding author †Equal contributors
Published: 19 December 2008 Received: 22 April 2008
Accepted: 19 December 2008
BMC Cancer 2008, 8:379 doi:10.1186/1471-2407-8-379
This article is available from: /1471-2407/8/379
© 2008 Zhao et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: The relationships between the expression of ID2, EBV-LMP1 and P16(INK4A) in
Chinese classical Hodgkin lymphoma are unknown and need exploring.
Methods: Samples of classical Hodgkin lymphoma from 60 Chinese patients were analyzed for the
expression of ID2, EBV-LMP1 and p16(INK4A) proteins by immunohistochemistry.
Results: ID2 protein was expressed in 83.3% of this group of classical Hodgkin lymphoma, staining
strongly in both cytoplas
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