adenovirus type 5 e1a-induced apoptosis in cox-2-overexpressing breast cancer cells5型腺病毒e1a-induced cox-2-overexpressing乳腺癌细胞凋亡.pdfVIP

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adenovirus type 5 e1a-induced apoptosis in cox-2-overexpressing breast cancer cells5型腺病毒e1a-induced cox-2-overexpressing乳腺癌细胞凋亡.pdf

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adenovirus type 5 e1a-induced apoptosis in cox-2-overexpressing breast cancer cells5型腺病毒e1a-induced cox-2-overexpressing乳腺癌细胞凋亡

Available online /content/9/4/R41 Vol 9 No 4 Open Access Research article Adenovirus type 5 E1A-induced apoptosis in COX-2-overexpressing breast cancer cells 1,2 1,2 3 1,2,4 Takeshi Sugimoto , Chandra Bartholomeusz , Ana M Tari and Naoto T Ueno 1Breast Cancer Translational Research Laboratory, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA 2Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA 3Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA 4Department of Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA Corresponding author: Naoto T Ueno, nueno@ Received: 7 Jul 2006 Revisions requested: 24 Aug 2006 Revisions received: 9 Jan 2007 Accepted: 5 Jul 2007 Published: 5 Jul 2007 Breast Cancer Research 2007, 9:R41 (doi:10.1186/bcr1739) This article is online at: /content/9/4/R41 © 2007 Sugimoto et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Suppression of Bcl-2 expression can overcome Results The two COX-2-overexpressing cell lines MDA-MB- cellular resistance to apoptosis induced by the adenovirus type 231-E1A and MDA-MB-435-E1A were more sensitive to 5 gene E1A in models of ovarian and breast cancer. Celecoxib, celecoxi