原创力文档accounting for multiple comparisons in a genome-wide association study (gwas)占全基因组关联研究(gwas)中的多重比较.pdfVIP
- 1、本文档共6页，可阅读全部内容。
- 2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
- 3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
accounting for multiple comparisons in a genome-wide association study (gwas)占全基因组关联研究(gwas)中的多重比较
Johnson et al. BMC Genomics 2010, 11:724
/1471-2164/11/724
RESEARCH ARTICLE Open Access
Accounting for multiple comparisons in a
genome-wide association study (GWAS)
1,2 1 1 3 1
Randall C Johnson , George W Nelson , Jennifer L Troyer , James A Lautenberger , Bailey D Kessing ,
1 3*
Cheryl A Winkler , Stephen J O’Brien
Abstract
Background: As we enter an era when testing millions of SNPs in a single gene association study will become the
standard, consideration of multiple comparisons is an essential part of determining statistical significance.
Bonferroni adjustments can be made but are conservative due to the preponderance of linkage disequilibrium (LD)
between genetic markers, and permutation testing is not always a viable option. Three major classes of corrections
have been proposed to correct the dependent nature of genetic data in Bonferroni adjustments: permutation
testing and related alternatives, principal components analysis (PCA), and analysis of blocks of LD across the
genome. We consider seven implementations of these commonly used methods using data from 1514 European
American participants genotyped for 700,078 SNPs in a GWAS for AIDS.
Results: A Bonferroni correction using the number of LD blocks found by the three algorithms implemented by
Haploview resulted in an insufficiently conservative threshold, corresponding to a genome-wide significance level
of a = 0.15 - 0.20. We observed a moderate increase in power when using PRESTO, SLIDE, and simpleℳ when
compared with traditional Bonferroni methods for population data genotyped on the Affymetrix 6.0 platform in
European Americans (a = 0.05 thresholds between 1 × 10-7 and 7 × 10-8).
您可能关注的文档
- a systematic review of the clinical effectiveness of acupuncture for allergic rhinitis系统回顾针灸治疗过敏性鼻炎的临床疗效.pdf
- a systematic review of the effectiveness of antimicrobial rinse-free hand sanitizers for prevention of illness-related absenteeism in elementary school children系统回顾抗菌rinse-free洗手液的有效性在小学生预防疾病旷工.pdf
- a systematic review of the diagnostic accuracy of prostate specific antigen系统回顾的前列腺特异抗原的诊断准确性.pdf
- a systematic review of the impact of stigma and nihilism on lung cancer outcomes系统回顾的耻辱和虚无主义对肺癌的影响结果.pdf
- a systematic review of tests for lymph node status in primary endometrial cancer系统回顾的测试在原发性子宫内膜癌淋巴结状态.pdf
- a systematic review of the quality of homeopathic clinical trials系统回顾的顺势疗法的临床试验的质量.pdf
- a systematic review of the literature examining the diagnostic efficacy of measurement of fractionated plasma free metanephrines in the biochemical diagnosis of pheochromocytoma文献的系统回顾检查各自为政的诊断疗效测量等离子体自由变肾上腺素的生化诊断嗜铬细胞瘤.pdf
- a systematic review with attempted network meta-analysis of asthma therapy recommended for five to eighteen year olds in gina steps three and four系统回顾与尝试网络荟萃分析哮喘治疗推荐5到18岁的吉娜步骤3和4.pdf
- a systematic review of the health, social and financial impacts of welfare rights advice delivered in healthcare settings系统回顾的健康、社会福利权利的建议和金融的影响在医疗设置.pdf
- a systematic survey in arabidopsis thaliana of transcription factors that modulate circadian parameters系统调查的拟南芥转录因子,调节生理参数.pdf
- accounting for risk in valuing forest carbon offsets会计风险评估森林碳补偿.pdf
- acculturation and use of health care services by turkish and moroccan migrants a cross-sectional population-based study文化适应和使用卫生保健服务由土耳其和摩洛哥移民横断面以人群为基础的研究.pdf
- acculturation and self-reported health among hispanics using a socio-behavioral model the north texas healthy heart study文化适应和自我报告健康在拉美裔使用socio-behavioral模型北德克萨斯心脏健康研究.pdf
- accounting for uncertainty when assessing association between copy number and disease a latent class model占时不确定性评估协会拷贝数与疾病之间潜在的类模型.pdf
- acculturation of pacific mothers in new zealand over time findings from the pacific islands families study文化移入太平洋的母亲在新西兰太平洋岛屿家庭研究的发现.pdf
- accounting for uncertainty in model-based prevalence estimation paratuberculosis control in dairy herds占基于模型的不确定性估计副结核患病率控制在奶牛.pdf
- accumulation and dissemination of prion protein in experimental sheep scrapie in the natural host朊蛋白的积累和传播实验羊痒病的自然宿主.pdf
- accumulation and transport of microbial-size particles in a pressure protected model burn unit cfd simulations and experimental evidence积累和运输microbial-size粒子在一个压力保护模型燃烧单元cfd模拟和实验证据.pdf
- accumulation and processing of a recombinant protein designed as a cleavable fusion to the endogenous rubisco lsu protein in chlamydomonas chloroplast重组蛋白的积累和处理设计成可分裂的融合在衣藻叶绿体内生rubisco lsu蛋白质.pdf
- accpbfret an imagej plugin for semi-automatic, fully corrected analysis of acceptor photobleaching fret imagesaccpbfret半自动imagej插件,完全纠正受体分析光漂白烦恼图像.pdf
文档评论（0）