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BMC Endocrine Disorders BioMed Central Research article Open Access A systematic review of the literature examining the diagnostic efficacy of measurement of fractionated plasma free metanephrines in the biochemical diagnosis of pheochromocytoma 1,2,3 2,4 5,6 6 Anna M Sawka* , Ally PH Prebtani , Lehana Thabane , Amiram Gafni , Mitchell Levine1,5,6 and William F Young Jr7 Address: 1Department of Internal Medicine, St. Josephs Healthcare, Hamilton, Ontario, L8N 4A6, Canada, 2Division of Endocrinology and Metabolism, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada, 3Hoffmann-La Roche Research Fellow in Health Economics, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada, 4Department of Internal Medicine, Hamilton General Hospital, Hamilton, Ontario, L8L 2X2, Canada, 5Centre for Evaluation of Medicines, St. Josephs Healthcare, Hamilton, Ontario, L8N 1G6, Canada, 6Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada and 7Division of Endocrinology, Metabolism, Nutrition, and Internal Medicine, Mayo Clinic, Rochester, MN, 55905, USA Email: Anna M Sawka* - sawkaam@; Ally PH Prebtani - sawkaam@; Lehana Thabane - sawkaam@; Amiram Gafni - sawkaam@; Mitchell Levine - sawkaam@; William F Young - sawkaam@ * Corresponding author Published: 29 June 2004 Received: 16 March 2004 Accepted: 29 June 2004 BMC Endocrine Disorders 2004, 4:2 doi:10.1186/1472-6823-4-2 This ar