原创力文档a simple index of lipid overaccumulation is a good marker of liver steatosis一个简单的脂质指数overaccumulation肝脂肪变性是一个很好的标志.pdfVIP
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a simple index of lipid overaccumulation is a good marker of liver steatosis一个简单的脂质指数overaccumulation肝脂肪变性是一个很好的标志
Bedogni et al. BMC Gastroenterology 2010, 10:98
/1471-230X/10/98
RESEARCH ARTICLE Open Access
A simple index of lipid overaccumulation is a
good marker of liver steatosis
1,2* 3 4 1
Giorgio Bedogni , Henry S Kahn , Stefano Bellentani , Claudio Tiribelli
Abstract
Background: Liver steatosis is often found in association with common cardiometabolic disorders, conditions that
may all occur in a shared context of abdominal obesity and dyslipidemia. An algorithm for identifying liver
steatosis is the fatty liver index (FLI). The lipid accumulation product (LAP) is an index formulated in a
representative sample of the US population to identify cardiometabolic disorders. Because FLI and LAP share two
components, namely waist circumference and fasting triglycerides, we evaluated the ability of LAP to identify liver
steatosis in the same study population from the Northern Italian town where FLI was initially developed.
Methods: We studied 588 individuals (59% males) aged 21 to 79 years. Liver steatosis was detected by
ultrasonography and coded ordinally as none, intermediate and severe. 44% of the individuals had liver steatosis.
Using proportional-odds ordinal logistic regression, we evaluated the ability of log-transformed LAP (lnLAP) to
identify liver steatosis. We considered the benefits to our model of including terms for sex, age, suspected liver
disease and ethanol intake. We calculated the 3-level probability of liver steatosis according to lnLAP and sex,
providing tables and nomograms for risk assessment.
Results: An ordinal proportional-odds model consisting of lnLAP and sex offered a reasonably accurate
identification of liver steatosis. The odds of more severe vs. less severe steatosis increased for increasing values of
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