原创力文档an accurate and interpretable model for sirna efficacy prediction一个准确和可翻译的sirna疗效预测模型.pdfVIP
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an accurate and interpretable model for sirna efficacy prediction一个准确和可翻译的sirna疗效预测模型
BMC Bioinformatics BioMed Central
Methodology article Open Access
An accurate and interpretable model for siRNA efficacy prediction
1 2 1
Jean-Philippe Vert* , Nicolas Foveau , Christian Lajaunie and
Yves Vandenbrouck2
Address: 1Centre for Computational Biology, Ecole des Mines de Paris, 35 rue Saint-Honoré, 77300 Fontainebleau, France and 2Laboratoire de
Biologie, Informatique, Mathématiques, Département Réponse et Dynamique Cellulaire, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble,
France
Email: Jean-Philippe Vert* - Jean-Philippe.Vert@ensmp.fr; Nicolas Foveau - Nicolas.Foveau@cea.fr;
Christian Lajaunie - Christian.Lajaunie@ensmp.fr; Yves Vandenbrouck - Yves.Vandenbrouck@cea.fr
* Corresponding author
Published: 30 November 2006 Received: 11 July 2006
Accepted: 30 November 2006
BMC Bioinformatics 2006, 7:520 doi:10.1186/1471-2105-7-520
This article is available from: /1471-2105/7/520
© 2006 Vert et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: The use of exogenous small interfering RNAs (siRNAs) for gene silencing has
quickly become a widespread molecular tool providing a powerful means for gene functional study
and new drug target identificat
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