an interactive tool for visualization of relationships between gene expression profiles一个交互式的可视化工具基因表达谱之间的关系.pdfVIP

BMC Bioinformatics BioMed Central Software Open Access An interactive tool for visualization of relationships between gene expression profiles Peter Ruzanov* and Steven JM Jones Address: Genome Sciences Centre, BC Cancer Research Centre, Ste 100-570 West 7th Ave Vancouver, BC V5Z 4S6, Canada Email: Peter Ruzanov* - pruzanov@bcgsc.ca; Steven JM Jones - sjones@bsgsc.ca * Corresponding author Published: 06 April 2006 Received: 27 September 2005 Accepted: 06 April 2006 BMC Bioinformatics2006, 7:193 doi:10.1186/1471-2105-7-193 This article is available from: /1471-2105/7/193 © 2006Ruzanov and Jones; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Application of phenetic methods to gene expression analysis proved to be a successful approach. Visualizing the results in a 3-dimentional space may further enhance these techniques. Results: We designed and built TreeBuilder3D, an interactive viewer for visualizing the hierarchical relationships between expression profiles such as SAGE libraries or microarrays. The program allows loading expression data as plain text files and visualizing the relative differences of the analyzed datasets in 3-dimensional space using various distan