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an insight into the sialotranscriptome of the west nile mosquito vector, culex tarsalis西尼罗河病毒的蚊子的洞察sialotranscriptome向量,库蚊tarsalis
Calvo et al. BMC Genomics 2010, 11:51
/1471-2164/11/51
RESEARCH ARTICLE Open Access
An insight into the sialotranscriptome of the
West Nile mosquito vector, Culex tarsalis
1 2 3 3 1 2
Eric Calvo , Irma Sanchez-Vargas , Amanda J Favreau , Kent D Barbian , Van M Pham , Kenneth E Olson ,
José MC Ribeiro1*
Abstract
Background: Saliva of adult female mosquitoes help sugar and blood feeding by providing enzymes and
polypeptides that help sugar digestion, control microbial growth and counteract their vertebrate host hemostasis
and inflammation. Mosquito saliva also potentiates the transmission of vector borne pathogens, including
arboviruses. Culex tarsalis is a bird feeding mosquito vector of West Nile Virus closely related to C. quinquefasciatus,
a mosquito relatively recently adapted to feed on humans, and the only mosquito of the genus Culex to have its
sialotranscriptome so far described.
Results: A total of 1,753 clones randomly selected from an adult female C. tarsalis salivary glands (SG) cDNA library
were sequenced and used to assemble a database that yielded 809 clusters of related sequences, 675 of which
were singletons. Primer extension experiments were performed in selected clones to further extend sequence
coverage, allowing for the identification of 283 protein sequences, 80 of which code for putative secreted proteins.
Conclusion: Comparison of the C. tarsalis sialotranscriptome with that of C. quinquefasciatus reveals accelerated
evolution of salivary proteins as compared to housekeeping proteins. The average amino acid identity among
salivary proteins is 70.1%, while that for housekeeping proteins is 91.2% (P 0.05), and the codon volatility of
secreted proteins is significantly higher
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