analysis of the role of retrotransposition in gene evolution in vertebrates分析的作用retrotransposition在脊椎动物基因进化.pdfVIP

BMC Bioinformatics BioMed Central Research article Open Access Analysis of the role of retrotransposition in gene evolution in vertebrates Zhan Yu, David Morais, Mahine Ivanga and Paul M Harrison* Address: Department of Biology, McGill University, Stewart Biology Building, 1205 Docteur Penfield Ave., Montreal, QC, H3A 1B1 Canada Email: Zhan Yu - zyu9@po-box.mcgill.ca; David Morais - david.delimamorais@mail.mcgill.ca; Mahine Ivanga - mahine.ivanga@crchul.ulaval.ca; Paul M Harrison* - paul.harrison@mcgill.ca * Corresponding author Published: 24 August 2007 Received: 7 April 2007 Accepted: 24 August 2007 BMC Bioinformatics 2007, 8:308 doi:10.1186/1471-2105-8-308 This article is available from: /1471-2105/8/308 © 2007 Yu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The dynamics of gene evolution are influenced by several genomic processes. One such process is retrotransposition, where an mRNA transcript is reverse-transcribed and reintegrated into the genomic DNA. Results: We have surveyed eight vertebrate genomes (human, chimp, dog, cow, rat, mouse, chicken and the puffer-fish T. nigriviridis), for putatively retrotransposed copies of genes. To gain a complete picture of the