原创力文档anemia and iron homeostasis in a cohort of hiv-infected patients in indonesia贫血和铁在印度尼西亚的艾滋病病毒感染者体内平衡.pdfVIP
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anemia and iron homeostasis in a cohort of hiv-infected patients in indonesia贫血和铁在印度尼西亚的艾滋病病毒感染者体内平衡
Wisaksana et al. BMC Infectious Diseases 2011, 11:213
/1471-2334/11/213
RESEARCH ARTICLE Open Access
Anemia and iron homeostasis in a cohort of HIV-
infected patients in Indonesia
1,2* 1 2,3 4 1 4
Rudi Wisaksana , Rachmat Sumantri , Agnes R Indrati , Aleta Zwitser , Hadi Jusuf , Quirijn de Mast ,
Reinout van Crevel2,4 and Andre van der Ven4
Abstract
Background: Anemia is a common clinical finding in HIV-infected patients and iron deficiency or redistribution
may contribute to the development of low hemoglobin levels. Iron overload is associated with a poor prognosis in
HIV and Hepatitis C virus infections. Iron redistribution may be caused by inflammation but possibly also by
hepatitis C co-infection. We examined the prevalence of anemia and its relation to mortality in a cohort of HIV
patients in a setting where injecting drug use (IDU) is a main mode of HIV transmission, and measured serum
ferritin and sTfR, in relation to anemia, inflammation, stage of HIV disease, ART and HCV infection.
Methods: Patient characteristics, ART history and iron parameters were recorded from adult HIV patients
presenting between September 2007 and August 2009 in the referral hospital for West Java, Indonesia. Kaplan-
Meier estimates and Cox’s regression were used to assess factors affecting survival. Logistic regression was used to
identity parameters associated with high ferritin concentrations.
Results: Anemia was found in 49.6% of 611 ART-naïve patients, with mild (Hb 10.5 - 12.99 g/dL for men; and 10.5 -
11.99 g/dL for women) anemia in 62.0%, and moderate to severe anemia (Hb 10.5 g/dL) in 38.0%. Anemia
remained an independent factor associated with death, also after adjustment for CD4 count and ART
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