原创力文档angiotensin converting enzyme dd genotype is associated with acute coronary syndrome severity and sudden cardiac death in taiwan a case-control emergency room study血管紧张素转换酶dd基因型与急性冠脉综合征严重程度和心脏性猝死在台湾一个急诊室病例对照研究.pdfVIP
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angiotensin converting enzyme dd genotype is associated with acute coronary syndrome severity and sudden cardiac death in taiwan a case-control emergency room study血管紧张素转换酶dd基因型与急性冠脉综合征严重程度和心脏性猝死在台湾一个急诊室病例对照研究
Chen et al. BMC Cardiovascular Disorders 2012, 12:6
/1471-2261/12/6
RESEARCH ARTICLE Open Access
Angiotensin converting enzyme DD genotype
is associated with acute coronary syndrome
severity and sudden cardiac death in Taiwan:
a case-control emergency room study
1,2† 3† 4,5† 1,6 7 8
Ying-Hsin Chen , Jui-Ming Liu , Ren-Jun Hsu , Sheng-Chuan Hu , Horng-Jyh Harn , Shee-Ping Chen ,
1,9 4 10,11* 4,5,11*
Jing-Ren Jeng , Chieh-Lin Wu , Jar-Yi Ho and Cheng-Ping Yu
Abstract
Background: Angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphisms have been
associated with acute coronary syndrome (ACS); however, several controversial results have also been found in
different studied populations. This hospital-based, emergency room, case-control study in Taiwan retrospectively
investigated 111 ACS patients, and 195 non-coronary subjects as a control group, to study the effects of ACE I/D
polymorphism in the most urgent ACS patients. ACE I/D polymorphisms were determined by polymerase chain
reaction-based assays and their associations with ACS risk, severity, and sudden cardiac death were determined.
Results: The ACE DD genotype was associated with ACS incidence. The DD genotype was associated with a
significant 4-fold higher risk of ACS in multivariate analysis (odds ratio (OR) = 4.295; 95% confidence interval (CI):
1.436-12.851, p = 0.009), and a 3.35-fold higher risk of acute myocardial infarction. DD genotype carriers also had
more than 3-fold higher risks of stenosis in all the three coronary arteries, left anterior descending artery infarction,
and anterior wall infarction. In addition, th
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