angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions血管生成在口腔上皮鳞状dysplasia-like现象前体病变.pdfVIP

Ju ly 22, 2009 EUROPEAN J OURNAL OF MEDICAL RESEARC 315 Eur J Med Res (2009) 14: 315-319 © I. Holzapfel Publishers 2009 ANGIOGENIC SQUAMOUS DYSPLASIA-LIKE P ENOMENON IN ORAL EPITHELIAL PRECURSOR LESIONS 1 1 2 3 4 3 C. H. Siar , V. P. A. Oo , H. Nagatsuka , K. Nakano , K.H. Ng , T. Kawakami 1Department of Oral Pathology, Oral Medicine and Periodontology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia, 2Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, Okayama, Japan, 3 ard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine, Shiojiri, J apan, 4Unit of Stomatology, Cancer Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia Abstract It is a multistep process that is mediated by vascular Statement of the pro blem: Dysplasia, the morphologi- endothelial cells and involves the response of existing cal yardstick of epithelial precursor lesions, is the col- vasculature to a series of protein mediators. Angio- lective term for a variety of architectural and cytologi- genic squamous dysplasia (ASD), a qualitative distinct cal changes within the altered oral epithelium. Angio- form of angiogenesis, was first described in pre-inva- genic squamous dysplasia (ASD), a distinct morpho- sive bron