apoe polymorphisms in narcolepsy载脂蛋白e多态性在嗜睡症.pdfVIP

BMC Medical Genetics BioMed Central BMC Medical Genetics :9 2001, 2 Research article ApoE polymorphisms in narcolepsy 1 2 1 2 Martin Gencik* , Norbert Dahmen , Stefan Wieczorek , Meike Kasten , Alexandra Gencikova1 and Jorg T Epplen1 Address: 1Molecular Human Genetics, Ruhr-University, D-44780 Bochum, Germany and 2Psychiatrische Klinik der Johannes-Gutenberg- Universitat, Mainz, Germany E-mail: Martin Gencik* - martin.gencik@ruhr-uni-bochum.de; Norbert Dahmen - ndahmen@mail.psychiatrie.klinik.uni-mainz.de; Stefan Wieczorek - stefanwieczorek@web.de; Meike Kasten - meike.kasten@t-online.de; Alexandra Gencikova - alexandra@gencik.de; Jorg T Epplen - joerg.t.epplen@ruhr-uni-bochum.de *Corresponding author Published: 9 August 2001 Received: 13 June 2001 Accepted: 9 August 2001 BMC Medical Genetics 2001, 2:9 This article is available from: /1471-2350/2/9 © 2001 Gencik et al; licensee BioMed Central Ltd. Verbatim copying and redistribution of this article are permitted in any medium for any non-com- mercial purpose, provided this notice is preserved along with the articles original URL. For commercial use, contact info@ Summary Background: Narcolepsy is a common neuropsychiatric disorder characterized by increased daytime sleepiness, cataplexy and hypnagogic hallucinations. Deficiency of the hypocretin neurotransmitter system was shown to be involved in the pathogenesis of narcolepsy in animals and men. There are several hints that neurodegeneration of